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===Cytology=== | ===Cytology=== | ||
Features:<ref>{{Ref APBR|682}}</ref> | Features:<ref>{{Ref APBR|682}}</ref> | ||
#Hyperchromasia - '''low power''' feature. | #Hyperchromasia - '''low power''' feature. | ||
#Irregular nuclear membrane - '''key feature'''. | #Irregular nuclear membrane - '''key feature'''. | ||
#Increased NC ratio. | #Increased NC ratio. | ||
#*Often uniform - when comparing malignant cells. | #*Often uniform - when comparing malignant cells. | ||
#"Large nuclei" (3-4X the size of a normal urothelial cell) - '''low power''' feature. | |||
#*These are not required for the diagnosis.<ref>SM. 12 January 2010.</ref> | |||
#*Large nuclei may be seen in benign umbrella cell, where the [[NC ratio]] is normal. | |||
#Nuclear size variation, >=2X other malign. looking cells - very useful. | #Nuclear size variation, >=2X other malign. looking cells - very useful. | ||
#+/-Large irregular nucleoli - common. | #+/-Large irregular nucleoli - common. | ||
Minimal criteria: | Minimal criteria: | ||
*Criteria # | *Criteria #1-3. † | ||
Notes: | Notes: |
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