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Difference between revisions of "Gastrointestinal stromal tumour"
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Gastrointestinal stromal tumour (view source)
Revision as of 17:28, 15 November 2020
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===Definition=== | ===Definition=== | ||
*Tumour resulting from a mutation in the KIT gene ''or'' PDGFRA (Platelet-derived growth factor receptor, alpha polypeptide) gene.<ref name=pmid17090188/> | *Tumour resulting from a mutation in the KIT gene ''or'' PDGFRA (Platelet-derived growth factor receptor, alpha polypeptide) gene.<ref name=pmid17090188/> | ||
*Cases wild-type for KIT or PDFGRA may harbour defects in the [[succinate dehydrogenase]] complex, NF-1, BRAF, or extremely rarely KRAS. | |||
===Epidemiology=== | ===Epidemiology=== | ||
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Notes: | Notes: | ||
*Small intestinal GISTs have a worse prognosis than gastric ones.<ref name=pmid17090188/> | *Small intestinal GISTs have a worse prognosis than gastric ones.<ref name=pmid17090188/> | ||
*GISTs almost never metastasize to the [[lymph node]]s | *GISTs almost never metastasize to the [[lymph node]]s (except for SDH-B deficient epithelioid GISTs) | ||
**Most common [[metastasis]] locations: [[liver]], abdominal soft tissue. | **Most common [[metastasis]] locations: [[liver]], abdominal soft tissue. | ||