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Difference between revisions of "Prostate cancer"
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→Situations where prostate adenocarcinoma may be missed{{cite journal |vauthors=Yang C, Humphrey PA |title=False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma |journal=Arch. Pathol. Lab. Med. |volume=144 |issue=3 |pages=326–334 |date=March 2020 |pmid=31729886 |doi=10.5858/arpa.2019-0456-RA |url=}}
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===Situations where prostate adenocarcinoma may be missed<ref>{{cite journal |vauthors=Yang C, Humphrey PA |title=False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma |journal=Arch. Pathol. Lab. Med. |volume=144 |issue=3 |pages=326–334 |date=March 2020 |pmid=31729886 |doi=10.5858/arpa.2019-0456-RA |url=}}</ref>=== | ===Situations where prostate adenocarcinoma may be missed<ref>{{cite journal |vauthors=Yang C, Humphrey PA |title=False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma |journal=Arch. Pathol. Lab. Med. |volume=144 |issue=3 |pages=326–334 |date=March 2020 |pmid=31729886 |doi=10.5858/arpa.2019-0456-RA |url=}}</ref>=== | ||
*Tissue artefacts (try levels and/or IHC) | *Tissue artefacts (try levels and/or IHC): | ||
**Crush artefact | **Crush artefact | ||
**Thick | **Thick sections | ||
** | **Aberrant H&E staining | ||
**Freezing artefact | **Freezing artefact | ||
*Minimal adenocarcinoma | **Cautery | ||
*Minimal adenocarcinoma (less than 1mm long or involving less than 5% of a core biopsy): | |||
*Prostatic adenocarcinoma variants that mimic benign: | *Prostatic adenocarcinoma variants that mimic benign: | ||
**[[Atrophic prostate carcinoma]] | **[[Atrophic prostate carcinoma]] | ||
**[[Pseudohyperplastic adenocarcinoma]] | **[[Pseudohyperplastic adenocarcinoma]] | ||
**[[Foamy gland adenocarcinoma]] | **[[Foamy gland adenocarcinoma]] | ||
**[[PIN-like adenocarcinoma]] | **[[PIN-like adenocarcinoma]] | ||
*Single | **Microcystic adenocarcinoma | ||
*Treatment effect | *Single cells of Gleason 5 adenocarcinoma (missed or mistaken for lymphocytes; try IHC) | ||
*Treatment effect (check clinical information and look for treatment effect in benign glands) | |||
===Prostate cancer grading=== | ===Prostate cancer grading=== | ||