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Difference between revisions of "Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma"
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Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma (view source)
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'''Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma''' is a pattern of [[endometrioid endometrial carcinoma]]. ''Microcystic elongated and fragmented glands'' is typically abbreviated as '''MELF'''.<ref name=pmid24061515>{{Cite journal | last1 = Euscher | first1 = E. | last2 = Fox | first2 = P. | last3 = Bassett | first3 = R. | last4 = Al-Ghawi | first4 = H. | last5 = Ali-Fehmi | first5 = R. | last6 = Barbuto | first6 = D. | last7 = Djordjevic | first7 = B. | last8 = Frauenhoffer | first8 = E. | last9 = Kim | first9 = I. | title = The pattern of myometrial invasion as a predictor of lymph node metastasis or extrauterine disease in low-grade endometrial carcinoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1728-36 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e318299f2ab | PMID = 24061515 }}</ref> | '''Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma''' is a pattern of [[endometrioid endometrial carcinoma]]. ''Microcystic elongated and fragmented glands'' is typically abbreviated as '''MELF'''.<ref name=pmid24061515>{{Cite journal | last1 = Euscher | first1 = E. | last2 = Fox | first2 = P. | last3 = Bassett | first3 = R. | last4 = Al-Ghawi | first4 = H. | last5 = Ali-Fehmi | first5 = R. | last6 = Barbuto | first6 = D. | last7 = Djordjevic | first7 = B. | last8 = Frauenhoffer | first8 = E. | last9 = Kim | first9 = I. | title = The pattern of myometrial invasion as a predictor of lymph node metastasis or extrauterine disease in low-grade endometrial carcinoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1728-36 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e318299f2ab | PMID = 24061515 }}</ref> | ||
==General== | |||
*MELF pattern a poor prognosticator.<ref name=pmid24487466/> | |||
==Microscopic== | ==Microscopic== | ||
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*Stromal mucin.<ref name=pmid19900084>{{cite journal |authors=Stewart CJ, Brennan BA, Leung YC, Little L |title=MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion |journal=Pathology |volume=41 |issue=5 |pages=454–9 |date=2009 |pmid=19900084 |doi=10.1080/00313020903041135 |url=}}</ref> | *Stromal mucin.<ref name=pmid19900084>{{cite journal |authors=Stewart CJ, Brennan BA, Leung YC, Little L |title=MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion |journal=Pathology |volume=41 |issue=5 |pages=454–9 |date=2009 |pmid=19900084 |doi=10.1080/00313020903041135 |url=}}</ref> | ||
**Mucinous differentiation common. | **Mucinous differentiation common. | ||
*Lymphovascular invasion | *Lymphovascular invasion more commmon than non-MELF carcinomas.<ref name=pmid24487466>{{cite journal |vauthor=Hertel JD, Huettner PC, Pfeifer JD |title=Lymphovascular space invasion in microcystic elongated and fragmented (MELF)-pattern well-differentiated endometrioid adenocarcinoma is associated with a higher rate of lymph node metastasis |journal=Int. J. Gynecol. Pathol. |volume=33 |issue=2 |pages=127–34 |date=March 2014 |pmid=24487466 |doi=10.1097/PGP.0b013e318285657b |url=}}</ref> | ||
==See also== | ==See also== | ||