Difference between revisions of "Epidermal growth factor receptor inhibitors"

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mutations
(EGFR)
(mutations)
Line 4: Line 4:
*EGFR (aka. ErbB1 or HER1) is a membranous receptor expressed in epithelial cells.  
*EGFR (aka. ErbB1 or HER1) is a membranous receptor expressed in epithelial cells.  
*Most of activating mutations in [[NSCLC]] are in Exon 18-21 (kinase domain).
*Most of activating mutations in [[NSCLC]] are in Exon 18-21 (kinase domain).
*45% of the mutations are p.DEL19, approx 40-45% are p.L858R, approx 2% are p.T790M.


==Drugs==
==Drugs==
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