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Difference between revisions of "Small cell carcinoma of the lung"
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Small cell carcinoma of the lung (view source)
Revision as of 22:14, 13 December 2019
, 22:14, 13 December 2019→IHC
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*Synaptophysin +ve. | *Synaptophysin +ve. | ||
**May be very weak. | **May be very weak. | ||
*TTF-1 +ve | *[[TTF-1]] +ve | ||
**Misch ''et al.'' reported: 82.8% positive (183 +ve of 221 cases).<ref name=pmid25889870>{{Cite journal | last1 = Misch | first1 = D. | last2 = Blum | first2 = T. | last3 = Boch | first3 = C. | last4 = Weiss | first4 = T. | last5 = Crolow | first5 = C. | last6 = Griff | first6 = S. | last7 = Mairinger | first7 = T. | last8 = Bauer | first8 = TT. | last9 = Kollmeier | first9 = J. | title = Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer. | journal = Diagn Pathol | volume = 10 | issue = | pages = 21 | month = Apr | year = 2015 | doi = 10.1186/s13000-015-0250-z | PMID = 25889870 }}</ref> | **Misch ''et al.'' reported: 82.8% positive (183 +ve of 221 cases).<ref name=pmid25889870>{{Cite journal | last1 = Misch | first1 = D. | last2 = Blum | first2 = T. | last3 = Boch | first3 = C. | last4 = Weiss | first4 = T. | last5 = Crolow | first5 = C. | last6 = Griff | first6 = S. | last7 = Mairinger | first7 = T. | last8 = Bauer | first8 = TT. | last9 = Kollmeier | first9 = J. | title = Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer. | journal = Diagn Pathol | volume = 10 | issue = | pages = 21 | month = Apr | year = 2015 | doi = 10.1186/s13000-015-0250-z | PMID = 25889870 }}</ref> | ||
**Wu ''et al.'' reported: 15 positive of 16 cases.<ref name=pmid16138374>{{Cite journal | last1 = Wu | first1 = M. | last2 = Szporn | first2 = AH. | last3 = Zhang | first3 = D. | last4 = Wasserman | first4 = P. | last5 = Gan | first5 = L. | last6 = Miller | first6 = L. | last7 = Burstein | first7 = DE. | title = Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers. | journal = Diagn Cytopathol | volume = 33 | issue = 4 | pages = 223-7 | month = Oct | year = 2005 | doi = 10.1002/dc.20337 | PMID = 16138374 }}</ref> | **Wu ''et al.'' reported: 15 positive of 16 cases.<ref name=pmid16138374>{{Cite journal | last1 = Wu | first1 = M. | last2 = Szporn | first2 = AH. | last3 = Zhang | first3 = D. | last4 = Wasserman | first4 = P. | last5 = Gan | first5 = L. | last6 = Miller | first6 = L. | last7 = Burstein | first7 = DE. | title = Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers. | journal = Diagn Cytopathol | volume = 33 | issue = 4 | pages = 223-7 | month = Oct | year = 2005 | doi = 10.1002/dc.20337 | PMID = 16138374 }}</ref> | ||
*CK7 -ve.<ref name=pmid10874668>{{Cite journal | last1 = Gyure | first1 = KA. | last2 = Morrison | first2 = AL. | title = Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. | journal = Mod Pathol | volume = 13 | issue = 6 | pages = 638-43 | month = Jun | year = 2000 | doi = 10.1038/modpathol.3880111 | PMID = 10874668 }}</ref> | *CK7 -ve.<ref name=pmid10874668>{{Cite journal | last1 = Gyure | first1 = KA. | last2 = Morrison | first2 = AL. | title = Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. | journal = Mod Pathol | volume = 13 | issue = 6 | pages = 638-43 | month = Jun | year = 2000 | doi = 10.1038/modpathol.3880111 | PMID = 10874668 }}</ref> | ||
*CK20 -ve.<ref name=pmid10874668/> | *[[CK20]] -ve.<ref name=pmid10874668/> | ||
Others: | Others: | ||
*p63 +ve in ~75-80% of the cases.<ref name=pmid15551738>{{Cite journal | last1 = Au | first1 = NH. | last2 = Gown | first2 = AM. | last3 = Cheang | first3 = M. | last4 = Huntsman | first4 = D. | last5 = Yorida | first5 = E. | last6 = Elliott | first6 = WM. | last7 = Flint | first7 = J. | last8 = English | first8 = J. | last9 = Gilks | first9 = CB. | title = P63 expression in lung carcinoma: a tissue microarray study of 408 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 3 | pages = 240-7 | month = Sep | year = 2004 | doi = | PMID = 15551738 }}</ref> | *[[p63]] +ve in ~75-80% of the cases.<ref name=pmid15551738>{{Cite journal | last1 = Au | first1 = NH. | last2 = Gown | first2 = AM. | last3 = Cheang | first3 = M. | last4 = Huntsman | first4 = D. | last5 = Yorida | first5 = E. | last6 = Elliott | first6 = WM. | last7 = Flint | first7 = J. | last8 = English | first8 = J. | last9 = Gilks | first9 = CB. | title = P63 expression in lung carcinoma: a tissue microarray study of 408 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 3 | pages = 240-7 | month = Sep | year = 2004 | doi = | PMID = 15551738 }}</ref> | ||
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