Difference between revisions of "Medulloblastoma"

Medulloblastoma (view source)

184 bytes added , 15:20, 20 November 2019

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 **Infantile, p53 wildtype: Usu. desmoplastic/nodular, 10q loss.
 **SHH-p53 mutant: Usu. large cell/anaplastic, 17q loss.
-*Group 3 (approx. 20%).
+*Non WNT/Non SHH:
-**Classic and large cell/anaplastic, MYC amplification, isochromosome 17q.
+**Group 3 (approx. 20%).
-*Group 4 (approx. 40%).
+***Classic and large cell/anaplastic, MYC amplification, isochromosome 17q.
-**Classic phenotype, MYCN amplification, isodicentric 17q.
+**Group 4 (approx. 40%).
-** Group 3+4 are often designated together as Non-Wnt/Non-SHH tumours.
+***Classic phenotype, MYCN amplification, isodicentric 17q.
+Note: Within Group 3+4 two  or  more  of  chromosome  7  gain,  chromosome 8 loss, and chromosome 11 loss separates standard risk medulloblastoma samples into favorable and classifies the remaining i17q diploid cases as high-risk.
 ==Prognosis==