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Difference between revisions of "Endometrial carcinoma"
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==Clinical== | ==Clinical== | ||
===Risk factors=== | |||
Risk factors for endometrial carcinoma - mnemonic ''COLD NUT'':<ref>TN07 GY40</ref> | Risk factors for endometrial carcinoma - mnemonic ''COLD NUT'':<ref>TN07 GY40</ref> | ||
*Cancer Hx (ovarian, breast, colon). | *Cancer Hx (ovarian, breast, colon). | ||
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*Tamoxifen use. | *Tamoxifen use. | ||
**Used for breast cancer; the risk is quite small<ref name=pmid19505894>{{Cite journal | last1 = Brown | first1 = K. | title = Is tamoxifen a genotoxic carcinogen in women? | journal = Mutagenesis | volume = 24 | issue = 5 | pages = 391-404 | month = Sep | year = 2009 | doi = 10.1093/mutage/gep022 | PMID = 19505894 }}</ref> or possibly negligent.<ref name=pmid19827879>{{Cite journal | last1 = Ashraf | first1 = M. | last2 = Biswas | first2 = J. | last3 = Majumdar | first3 = S. | last4 = Nayak | first4 = S. | last5 = Alam | first5 = N. | last6 = Mukherjee | first6 = KK. | last7 = Gupta | first7 = S. | title = Tamoxifen use in Indian women--adverse effects revisited. | journal = Asian Pac J Cancer Prev | volume = 10 | issue = 4 | pages = 609-12 | month = | year = | doi = | PMID = 19827879 }}</ref> | **Used for breast cancer; the risk is quite small<ref name=pmid19505894>{{Cite journal | last1 = Brown | first1 = K. | title = Is tamoxifen a genotoxic carcinogen in women? | journal = Mutagenesis | volume = 24 | issue = 5 | pages = 391-404 | month = Sep | year = 2009 | doi = 10.1093/mutage/gep022 | PMID = 19505894 }}</ref> or possibly negligent.<ref name=pmid19827879>{{Cite journal | last1 = Ashraf | first1 = M. | last2 = Biswas | first2 = J. | last3 = Majumdar | first3 = S. | last4 = Nayak | first4 = S. | last5 = Alam | first5 = N. | last6 = Mukherjee | first6 = KK. | last7 = Gupta | first7 = S. | title = Tamoxifen use in Indian women--adverse effects revisited. | journal = Asian Pac J Cancer Prev | volume = 10 | issue = 4 | pages = 609-12 | month = | year = | doi = | PMID = 19827879 }}</ref> | ||
====Family history==== | |||
Several syndromes are seen in association with endometrial cancer:<ref>{{cite journal |author=Okuda T, Sekizawa A, Purwosunu Y, ''et al.'' |title=Genetics of endometrial cancers |journal=Obstet Gynecol Int |volume=2010 |issue= |pages=984013 |year=2010 |pmid=20396392 |pmc=2852605 |doi=10.1155/2010/984013 |url=}}</ref> | |||
*[[Cowden syndrome]] (PTEN mutation) - most common. | |||
**Associated with ''endometrioid endometrial carcinoma''. | |||
*[[Lynch syndrome]] (MSH2/MSH6 protein complex - mutations). | |||
**Associated with ''non-endometrioid endometrial carcinoma''. | |||
**Autosomal dominant. | |||
===Management=== | ===Management=== | ||