Difference between revisions of "Neurodegenerative diseases"

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==Neuronal Intermediate Filament Inclusion Disease==
==Neuronal Intermediate Filament Inclusion Disease==
* AKA: NIFID.
* AKA: NIFID.
* Hyaline conglomerates (brightly eosinophilic branching fibrillar structures embedded in a round, well-delineated, glassy vacuole).  
* Sporadic early‐onset frontotemporal dementia, motor neuron disease, extrapyramidal motor symptoms.
* FUS+ve (heterogenous).
* Hyaline conglomerates (brightly eosinophilic branching fibrillar structures embedded in a round, well-delineated, glassy vacuole).
* Deposits in cerebral cortex, hippocampus, basal ganglia, thalamus, cerebellar dentate, numerous brainstem nuclei and lower motor neurons.  
* FUS+ve/EWS+ve/TAF15+ve (heterogenous).
** FET+ve filamentous nuclear inclusions in the hippocampus.  
* Ubiquitin +/-ve.
* Ubiquitin +/-ve.
* NF +ve (some subunits).
* NF +ve (some subunits).
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