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Difference between revisions of "TRK fusions"
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Testing: | Testing: | ||
*RNA-based next generation sequencing. | *RNA-based next generation sequencing. | ||
*[[Immunohistochemistry]]<ref name=pmid28719467>{{Cite journal | last1 = Hechtman | first1 = JF. | last2 = Benayed | first2 = R. | last3 = Hyman | first3 = DM. | last4 = Drilon | first4 = A. | last5 = Zehir | first5 = A. | last6 = Frosina | first6 = D. | last7 = Arcila | first7 = ME. | last8 = Dogan | first8 = S. | last9 = Klimstra | first9 = DS. | title = Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. | journal = Am J Surg Pathol | volume = 41 | issue = 11 | pages = 1547-1551 | month = Nov | year = 2017 | doi = 10.1097/PAS.0000000000000911 | PMID = 28719467 }}</ref> - limited sensitivity | *[[Immunohistochemistry]]<ref name=pmid28719467>{{Cite journal | last1 = Hechtman | first1 = JF. | last2 = Benayed | first2 = R. | last3 = Hyman | first3 = DM. | last4 = Drilon | first4 = A. | last5 = Zehir | first5 = A. | last6 = Frosina | first6 = D. | last7 = Arcila | first7 = ME. | last8 = Dogan | first8 = S. | last9 = Klimstra | first9 = DS. | title = Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. | journal = Am J Surg Pathol | volume = 41 | issue = 11 | pages = 1547-1551 | month = Nov | year = 2017 | doi = 10.1097/PAS.0000000000000911 | PMID = 28719467 }}</ref> - limited sensitivity for leiomyosarcoma + others tumours. | ||
*FISH breakapart probes. | *FISH breakapart probes. | ||
*DNA NGS<ref>{{Cite journal | last1 = Cocco | first1 = E. | last2 = Scaltriti | first2 = M. | last3 = Drilon | first3 = A. | title = NTRK fusion-positive cancers and TRK inhibitor therapy. | journal = Nat Rev Clin Oncol | volume = 15 | issue = 12 | pages = 731-747 | month = Dec | year = 2018 | doi = 10.1038/s41571-018-0113-0 | PMID = 30333516 }} | *DNA NGS<ref>{{Cite journal | last1 = Cocco | first1 = E. | last2 = Scaltriti | first2 = M. | last3 = Drilon | first3 = A. | title = NTRK fusion-positive cancers and TRK inhibitor therapy. | journal = Nat Rev Clin Oncol | volume = 15 | issue = 12 | pages = 731-747 | month = Dec | year = 2018 | doi = 10.1038/s41571-018-0113-0 | PMID = 30333516 }} | ||