Difference between revisions of "SMARCB1-deficient sinonasal carcinoma"

SMARCB1-deficient sinonasal carcinoma (view source)

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 '''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal  | last1 = Agaimy | first1 = A. | last2 = Hartmann | first2 = A. | last3 = Antonescu | first3 = CR. | last4 = Chiosea | first4 = SI. | last5 = El-Mofty | first5 = SK. | last6 = Geddert | first6 = H. | last7 = Iro | first7 = H. | last8 = Lewis | first8 = JS. | last9 = Märkl | first9 = B. | title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. | journal = Am J Surg Pathol | volume = 41 | issue = 4 | pages = 458-471 | month = Apr | year = 2017 | doi = 10.1097/PAS.0000000000000797 | PMID = 28291122 }}</ref>
+==General==
+*Rare - large series from 2017 has 39 cases.<ref name=pmid28291122/>
+*Large age range (19-89 years old).
+*Often present at high stage T3 or T4.
+*Aggressive clinical course.
+==Gross==
+*Most often in ethmoid sinus +/- nasal cavity.
 ==Microscopic==
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 DDx:
-*[[SNUC]].
+*[[Sinonasal undifferentiated carcinoma]] (SNUC).
 *[[Squamous cell carcinoma of the head and neck]].