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Difference between revisions of "ALK translocation renal cell carcinoma"
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ALK translocation renal cell carcinoma (view source)
Revision as of 17:41, 17 March 2019
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*Extremely rare. | *Extremely rare. | ||
*May be related to ''[[renal medullary carcinoma]]'' which is reported to have an ALK rearrangement - t(2;10)(p23;q22).<ref name=pmid21213368>{{Cite journal | last1 = Mariño-Enríquez | first1 = A. | last2 = Ou | first2 = WB. | last3 = Weldon | first3 = CB. | last4 = Fletcher | first4 = JA. | last5 = Pérez-Atayde | first5 = AR. | title = ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. | journal = Genes Chromosomes Cancer | volume = 50 | issue = 3 | pages = 146-53 | month = Mar | year = 2011 | doi = 10.1002/gcc.20839 | PMID = 21213368 }}</ref> | *May be related to ''[[renal medullary carcinoma]]'' which is reported to have an ALK rearrangement - t(2;10)(p23;q22).<ref name=pmid21213368>{{Cite journal | last1 = Mariño-Enríquez | first1 = A. | last2 = Ou | first2 = WB. | last3 = Weldon | first3 = CB. | last4 = Fletcher | first4 = JA. | last5 = Pérez-Atayde | first5 = AR. | title = ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. | journal = Genes Chromosomes Cancer | volume = 50 | issue = 3 | pages = 146-53 | month = Mar | year = 2011 | doi = 10.1002/gcc.20839 | PMID = 21213368 }}</ref> | ||
==Microscopic== | |||
Features: | |||
*Mix of morphologies - rhabdoid, sarcomatoid, "[[unclassified renal cell carcinoma]]". | |||
DDx: | |||
*[[Unclassified renal cell carcinoma]] | |||
*[[Renal medullary carcinoma]]. | |||
==IHC== | |||
*ALK +ve. | |||
*[[SMARCB1]] -ve. | |||
==See also== | ==See also== | ||