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Difference between revisions of "Chondro-osseous tumours"
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→IHC: +FLI-1
(→Molecular diagnostics: tweak + wikify) |
(→IHC: +FLI-1) |
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Features:<ref name=Ref_WMSP651>{{Ref WMSP|651}}</ref> | Features:<ref name=Ref_WMSP651>{{Ref WMSP|651}}</ref> | ||
*CD99 +ve -- 1. diffuse, 2. plasma membrane staining; both required -- most specific. | *CD99 +ve -- 1. diffuse, 2. plasma membrane staining; both required -- most specific. | ||
*FLI-1 +ve.<ref name=pmid15001993>{{cite journal |author=Rossi S, Orvieto E, Furlanetto A, Laurino L, Ninfo V, Dei Tos AP |title=Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody |journal=Mod. Pathol. |volume=17 |issue=5 |pages=547–52 |year=2004 |month=May |pmid=15001993 |doi=10.1038/modpathol.3800065 |url=http://www.nature.com/modpathol/journal/v17/n5/full/3800065a.html}}</ref> | |||
*CD45 -ve. | *CD45 -ve. | ||
**Done to r/o [[lymphoma]]. | **Done to r/o [[lymphoma]]. | ||
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**Angiomatoid fibrous histiocytoma. | **Angiomatoid fibrous histiocytoma. | ||
**[[Desmoplastic small round cell tumour]]. | **[[Desmoplastic small round cell tumour]]. | ||
*FLI-1 +ve:<ref name=pmid15001993/> | |||
**Vascular neoplasms. | |||
**-/+Merkel cell carcinoma. | |||
**-/+Melanoma. | |||
===Molecular diagnostics=== | ===Molecular diagnostics=== | ||