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Difference between revisions of "Small intestine"
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The '''small intestine''', also '''small bowel''', is a relatively well-behaved piece of machinery from the perspective of [[pathology]]. It is uncommonly affected by malignancies, relative to its length when compared to the [[colon]] and [[rectum]]. | The '''small intestine''', also '''small bowel''', is a relatively well-behaved piece of machinery from the perspective of [[pathology]]. It is uncommonly affected by malignancies, relative to its length when compared to the [[colon]] and [[rectum]]. | ||
=Normal= | |||
==Anatomy== | ==Anatomy== | ||
Consists of three segments: | Consists of three segments: | ||
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In the context of bowel obstructions and IBD, pathologists often see resected stomas (that were put in place emergently). These specimens are usually fairly straight forward. | In the context of bowel obstructions and IBD, pathologists often see resected stomas (that were put in place emergently). These specimens are usually fairly straight forward. | ||
==Histology== | ==Histology== | ||
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The ''[[Gastrointestinal pathology]]'' article covers basic histology of the GI tract. | The ''[[Gastrointestinal pathology]]'' article covers basic histology of the GI tract. | ||
=[[Immunohistochemistry]]= | |||
*Normal small intestine is CK20 +ve... while adenocarcinoma of the small bowel may be CK20 -ve.<ref>{{cite journal |author=Chen ZM, Wang HL |title=Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine |journal=Am. J. Surg. Pathol. |volume=28 |issue=10 |pages=1352–9 |year=2004 |month=October |pmid=15371952 |doi= |url=}}</ref> | |||
=The segments= | |||
==Duodenum== | ==Duodenum== | ||
{{main|Duodenum}} | {{main|Duodenum}} | ||
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*May be assoc. with hypogammaglobulinemia.<ref name=pmid8782302>{{cite journal |author=Yamaue H, Tanimura H, Ishimoto K, Morikawa Y, Kakudo K |title=Nodular lymphoid hyperplasia of the terminal ileum: report of a case and the findings of an immunological analysis |journal=Surg. Today |volume=26 |issue=6 |pages=431-4 |year=1996 |pmid=8782302 |doi= |url=}}</ref> | *May be assoc. with hypogammaglobulinemia.<ref name=pmid8782302>{{cite journal |author=Yamaue H, Tanimura H, Ishimoto K, Morikawa Y, Kakudo K |title=Nodular lymphoid hyperplasia of the terminal ileum: report of a case and the findings of an immunological analysis |journal=Surg. Today |volume=26 |issue=6 |pages=431-4 |year=1996 |pmid=8782302 |doi= |url=}}</ref> | ||
=Specific conditions= | |||
==Small bowel neoplasms== | ==Small bowel neoplasms== | ||
*Adenocarcinoma - like colonic. | *Adenocarcinoma - like colonic. | ||
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**+/-Adjacent mucosal erosions/granulation tissue. | **+/-Adjacent mucosal erosions/granulation tissue. | ||
=See also= | |||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Gastrointestinal pathology]]. | *[[Gastrointestinal pathology]]. | ||
*[[Colon]]. | *[[Colon]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||