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Difference between revisions of "TRK fusions"
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*[[Congenital-infantile fibrosarcoma]].<ref name=pmid11242790 >{{Cite journal | last1 = Sheng | first1 = WQ. | last2 = Hisaoka | first2 = M. | last3 = Okamoto | first3 = S. | last4 = Tanaka | first4 = A. | last5 = Meis-Kindblom | first5 = JM. | last6 = Kindblom | first6 = LG. | last7 = Ishida | first7 = T. | last8 = Nojima | first8 = T. | last9 = Hashimoto | first9 = H. | title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. | journal = Am J Clin Pathol | volume = 115 | issue = 3 | pages = 348-55 | month = Mar | year = 2001 | doi = 10.1309/3H24-E7T7-V37G-AKKQ | PMID = 11242790 }}</ref> | *[[Congenital-infantile fibrosarcoma]].<ref name=pmid11242790 >{{Cite journal | last1 = Sheng | first1 = WQ. | last2 = Hisaoka | first2 = M. | last3 = Okamoto | first3 = S. | last4 = Tanaka | first4 = A. | last5 = Meis-Kindblom | first5 = JM. | last6 = Kindblom | first6 = LG. | last7 = Ishida | first7 = T. | last8 = Nojima | first8 = T. | last9 = Hashimoto | first9 = H. | title = Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. | journal = Am J Clin Pathol | volume = 115 | issue = 3 | pages = 348-55 | month = Mar | year = 2001 | doi = 10.1309/3H24-E7T7-V37G-AKKQ | PMID = 11242790 }}</ref> | ||
*Cellular [[mesoblastic nephroma]].<ref name=pmid29893456>{{Cite journal | last1 = Halalsheh | first1 = H. | last2 = McCarville | first2 = MB. | last3 = Neel | first3 = M. | last4 = Reynolds | first4 = M. | last5 = Cox | first5 = MC. | last6 = Pappo | first6 = AS. | title = Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma. | journal = Pediatr Blood Cancer | volume = 65 | issue = 10 | pages = e27271 | month = Oct | year = 2018 | doi = 10.1002/pbc.27271 | PMID = 29893456 }}</ref><ref name=pmid29683818>{{Cite journal | last1 = Rudzinski | first1 = ER. | last2 = Lockwood | first2 = CM. | last3 = Stohr | first3 = BA. | last4 = Vargas | first4 = SO. | last5 = Sheridan | first5 = R. | last6 = Black | first6 = JO. | last7 = Rajaram | first7 = V. | last8 = Laetsch | first8 = TW. | last9 = Davis | first9 = JL. | title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. | journal = Am J Surg Pathol | volume = 42 | issue = 7 | pages = 927-935 | month = Jul | year = 2018 | doi = 10.1097/PAS.0000000000001062 | PMID = 29683818 }}</ref> | *Cellular [[mesoblastic nephroma]].<ref name=pmid29893456>{{Cite journal | last1 = Halalsheh | first1 = H. | last2 = McCarville | first2 = MB. | last3 = Neel | first3 = M. | last4 = Reynolds | first4 = M. | last5 = Cox | first5 = MC. | last6 = Pappo | first6 = AS. | title = Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma. | journal = Pediatr Blood Cancer | volume = 65 | issue = 10 | pages = e27271 | month = Oct | year = 2018 | doi = 10.1002/pbc.27271 | PMID = 29893456 }}</ref><ref name=pmid29683818>{{Cite journal | last1 = Rudzinski | first1 = ER. | last2 = Lockwood | first2 = CM. | last3 = Stohr | first3 = BA. | last4 = Vargas | first4 = SO. | last5 = Sheridan | first5 = R. | last6 = Black | first6 = JO. | last7 = Rajaram | first7 = V. | last8 = Laetsch | first8 = TW. | last9 = Davis | first9 = JL. | title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. | journal = Am J Surg Pathol | volume = 42 | issue = 7 | pages = 927-935 | month = Jul | year = 2018 | doi = 10.1097/PAS.0000000000001062 | PMID = 29683818 }}</ref> | ||
*NTRK1 fusions occasionally in [[Glioblastoma]] (1-2%).<ref>{{Cite journal | last1 = Xu | first1 = T. | last2 = Wang | first2 = H. | last3 = Huang | first3 = X. | last4 = Li | first4 = W. | last5 = Huang | first5 = Q. | last6 = Yan | first6 = Y. | last7 = Chen | first7 = J. | title = Gene Fusion in Malignant Glioma: An Emerging Target for Next-Generation Personalized Treatment. | journal = Transl Oncol | volume = 11 | issue = 3 | pages = 609-618 | month = Jun | year = 2018 | doi = 10.1016/j.tranon.2018.02.020 | PMID = 29571074 }}</ref> | |||
==Drugs== | ==Drugs== | ||