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Difference between revisions of "Medulloblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Medulloblastoma with rosettes.jpg | |||
| Width = | |||
| Caption = Classic medulloblastoma [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = small cell round blue tumous. | |||
| Stains = Reticulin +ve (in desmoplastic MB) | |||
| IHC = MAP2+ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = cerebellar. | |||
| Grossing = | |||
| Site = brain - usu. [[cerebellum]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common - esp. in children | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = subtype-dependent (WHO Grade IV) | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Medulloblastoma''' is a [[malignant]] [[small round cell tumour]] that is found in the [[cerebellum]] or dorsal brainstem. It is the most common malignant CNS tumour in children. | '''Medulloblastoma''' is a [[malignant]] [[small round cell tumour]] that is found in the [[cerebellum]] or dorsal brainstem. It is the most common malignant CNS tumour in children. | ||
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**Infantile, p53 wildtype: Usu. desmoplastic/nodular, 10q loss. | **Infantile, p53 wildtype: Usu. desmoplastic/nodular, 10q loss. | ||
**SHH-p53 mutant: Usu. large cell/anaplastic, 17q loss. | **SHH-p53 mutant: Usu. large cell/anaplastic, 17q loss. | ||
*Group 3 (approx. 20%). | *Non WNT/Non SHH: | ||
**Classic and large cell/anaplastic, MYC amplification, isochromosome 17q. | **Group 3 (approx. 20%). | ||
*Group 4 (approx. 40%). | ***Classic and large cell/anaplastic, MYC amplification, isochromosome 17q. | ||
**Classic phenotype, MYCN amplification, isodicentric 17q. | **Group 4 (approx. 40%). | ||
***Classic phenotype, MYCN amplification, isodicentric 17q. | |||
Note: Within Group 3+4 two or more of chromosome 7 gain, chromosome 8 loss, and chromosome 11 loss separates standard risk medulloblastoma samples into favorable and classifies the remaining i17q diploid cases as high-risk. | |||
==Prognosis== | ==Prognosis== | ||