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Difference between revisions of "Hodgkin lymphoma"
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more on IHC pattern
m (few more tweaks) |
m (more on IHC pattern) |
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==IHC== | ==IHC== | ||
Abbreviated panel:<ref name=Ref_WMSP568>{{Ref_WMSP|568}}</ref> | Abbreviated panel:<ref name=Ref_WMSP568>{{Ref_WMSP|568}}</ref> | ||
*CD30 Reed-Sternberg cells (RSCs) +ve ~98% | *CD30 Reed-Sternberg cells (RSCs) +ve ~98% (beware of mis-interpreting CD30+ activated lymphoid cells) | ||
*CD15 Reed-Sternberg cells +ve ~80%, stains neutrophils. | *CD15 Reed-Sternberg cells +ve ~80%, stains neutrophils. | ||
*Both CD30 and CD15 are classically positive in a membranous and Golgi pattern | |||
*MUM1 +ve | *MUM1 +ve | ||
*CD45 '''often negative''' in RSCs. | *CD45 '''often negative''' in RSCs. | ||
*CD20 may stain RSCs (usually negative, but can be weak). | *CD20 may stain RSCs (usually negative, but can be weak). | ||
*PAX5 +ve | *PAX5 +ve, though said to be weaker than background normal B-cells<ref name=Ref_APBR683>{{Ref APBR|683}}</ref> | ||
Additional - for completeness: | Additional - for completeness: | ||
*CD3 (T lymphocytes) | *CD3 (T lymphocytes) - negative in RSCs | ||
*OCT2/BOB1 negative (co-transcription factors for immunoglobulin production, one or the other is usually negative) | |||
*40% are EBV positive. | *40% are EBV positive. | ||