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Difference between revisions of "Marginal zone lymphoma"
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a few minor points
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==General== | ==General== | ||
* | *The MALTomas arise in the context chronic infective or inflammatory conditions, e.g. [[Sjögren disease]] ([[salivary gland]]), [[Hashimoto thyroiditis]] ([[thyroid gland]]), [[Helicobacter pylori gastritis]] ([[stomach]]).<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8|326}}</ref> | ||
===Classification=== | ===Classification=== | ||
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*#Splenic marginal zone lymphoma (SMZL). | *#Splenic marginal zone lymphoma (SMZL). | ||
*#Nodal marginal zone lymphoma (NMZL). | *#Nodal marginal zone lymphoma (NMZL). | ||
Whilst there are some immunohistochemical differences between the 3 types, separating them out depends on clinical features and radiological findings, e.g. splenic marginal zone lymphoma with spread to lymph nodes may be indistinguishable from primary nodal marginal zone lymphoma. | |||
==Microscopic== | ==Microscopic== | ||
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DDx: | DDx: | ||
*Other [[small cell lymphomas]]. | *Other [[small cell lymphomas]]. | ||
*Marginal zone hyperplasia | |||
*[[DLBCL]] - should be a distinctive region at low power.{{fact}} | *[[DLBCL]] - should be a distinctive region at low power.{{fact}} | ||
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[[File:5 3078322547565 sl 5.png| MALT lymphoma of stomach]]<br> | [[File:5 3078322547565 sl 5.png| MALT lymphoma of stomach]]<br> | ||
Extrazonal marginal zone lymphojma of mucosa-associates lymphoid tissue (MALT lymphoma) in stomach of 64 Year old man, identified in sleeve gastrectomy performed for weight loss. A. Predominantly submucosal blue masses without definite follicles. B. Small round to irregular lymphoid cells surround the most inferior pits. C. Non-neoplastic T cells are seen in abundance, sometime within pit epithelium. D. Neoplastic B cells mass and surround pits, but do not extensively invade the epithelium; lymphoepithelial lesions were not seen. E. Cancer cells expressed BCL2. Cancer cells were negative for CD5, CD10, and cyclin D1. | Extrazonal marginal zone lymphojma of mucosa-associates lymphoid tissue (MALT lymphoma) in stomach of 64 Year old man, identified in sleeve gastrectomy performed for weight loss. A. Predominantly submucosal blue masses without definite follicles. B. Small round to irregular lymphoid cells surround the most inferior pits. C. Non-neoplastic T cells are seen in abundance, sometime within pit epithelium. D. Neoplastic B cells mass and surround pits, but do not extensively invade the epithelium; lymphoepithelial lesions were not seen. E. Cancer cells expressed BCL2. Cancer cells were negative for CD5, CD10, and cyclin D1. | ||
www: | www: | ||