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→Chordoid glioma of the third ventricle: update who2016
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===Chordoid glioma of the third ventricle=== | ===Chordoid glioma of the third ventricle=== | ||
* WHO grade II. | * WHO grade II. | ||
* Slowly growing, non-invasive. | * Slowly growing, non-invasive, in adults. | ||
* Clusters of epithelioid cells in mucinous stroma. | * Clusters of epithelioid cells in mucinous stroma. | ||
* Lymphocytic infiltrates, adjacent Rosenthal fibers. | * Lymphocytic infiltrates, adjacent Rosenthal fibers. | ||
* Fibrosis may be present. | |||
* Few mitoses. | * Few mitoses. | ||
* GFAP+ve, MIB-1 1-3%. | * [[GFAP]]+ve, MIB-1 1-3%. | ||
* [[TTF-1]]+ve | |||
* PRKCA D463H mutations.<ref>{{Cite journal | last1 = Goode | first1 = B. | last2 = Mondal | first2 = G. | last3 = Hyun | first3 = M. | last4 = Ruiz | first4 = DG. | last5 = Lin | first5 = YH. | last6 = Van Ziffle | first6 = J. | last7 = Joseph | first7 = NM. | last8 = Onodera | first8 = C. | last9 = Talevich | first9 = E. | title = A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. | journal = Nat Commun | volume = 9 | issue = 1 | pages = 810 | month = 02 | year = 2018 | doi = 10.1038/s41467-018-02826-8 | PMID = 29476136 }}</ref> | * PRKCA D463H mutations.<ref>{{Cite journal | last1 = Goode | first1 = B. | last2 = Mondal | first2 = G. | last3 = Hyun | first3 = M. | last4 = Ruiz | first4 = DG. | last5 = Lin | first5 = YH. | last6 = Van Ziffle | first6 = J. | last7 = Joseph | first7 = NM. | last8 = Onodera | first8 = C. | last9 = Talevich | first9 = E. | title = A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. | journal = Nat Commun | volume = 9 | issue = 1 | pages = 810 | month = 02 | year = 2018 | doi = 10.1038/s41467-018-02826-8 | PMID = 29476136 }}</ref> | ||