Difference between revisions of "Chronic myeloid leukemia"

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IHC not usually helpful other than to enumerate blasts
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m (IHC not usually helpful other than to enumerate blasts)
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===IHC===
===IHC===
Features:<ref>{{Cite journal  | last1 = Muñoz | first1 = L. | last2 = Bellido | first2 = M. | last3 = Sierra | first3 = J. | last4 = Nomdedéu | first4 = JF. | title = Flow cytometric detection of B cell abnormal maturation in chronic myeloid leukemia. | journal = Leukemia | volume = 14 | issue = 2 | pages = 339-40 | month = Feb | year = 2000 | doi =  | PMID = 10673756 |URL = http://www.nature.com/leu/journal/v14/n2/full/2401549a.html }}</ref> (???)
Rarely required. CML may transform into a blast phase, typically myeloid blasts, but lymphoblasts may also be seen. These blasts are typically CD34 and/or CD117 positive. The myeloid blasts will express myeloid markers and the lymphoblasts will shows lymphoid markers.
*Chronic:
**CD20+ CD19+ CD10-.
*Accelerated:
**CD20+ CD19+ CD10+.
*Blast:
**CD20- CD19+ CD10+.
**CD34+ TdT+.<ref>URL: [http://path.upmc.edu/cases/case271.html http://path.upmc.edu/cases/case271.html]. Accessed on: 14 January 2012.</ref>


===Molecular===
===Molecular===
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