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Difference between revisions of "Renal cell carcinoma grading"
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==General== | ==General== | ||
There are two systems: | There are two systems: | ||
*''[[ISUP]] grading'':<ref name=pmid24025520>{{cite journal |author=Delahunt B, Cheville JC, Martignoni G, ''et al.'' |title=The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters |journal=Am. J. Surg. Pathol. |volume=37 |issue=10 |pages=1490–504 |year=2013 |month=October |pmid=24025520 |doi=10.1097/PAS.0b013e318299f0fb |url=}}</ref> | *''[[ISUP]] grading'':<ref name=pmid24025520>{{cite journal |author=Delahunt B, Cheville JC, Martignoni G, ''et al.'' |title=The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters |journal=Am. J. Surg. Pathol. |volume=37 |issue=10 |pages=1490–504 |year=2013 |month=October |pmid=24025520 |doi=10.1097/PAS.0b013e318299f0fb |url=}}</ref> | ||
**Newer and less complicated. | **Newer and less complicated. | ||
**Mostly based on [[nucleoli|nucleolar size]] and to a much lesser degree on size and morphology | **Mostly based on [[nucleoli|nucleolar size]] and to a much lesser degree on size and morphology | ||
**Developed based on ''Fuhrman grading''. | **Developed based on ''Fuhrman grading''. | ||
**Validated in | **Validated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal | last1 = Dagher | first1 = J. | last2 = Delahunt | first2 = B. | last3 = Rioux-Leclercq | first3 = N. | last4 = Egevad | first4 = L. | last5 = Srigley | first5 = JR. | last6 = Coughlin | first6 = G. | last7 = Dunglinson | first7 = N. | last8 = Gianduzzo | first8 = T. | last9 = Kua | first9 = B. | title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. | journal = Histopathology | volume = 71 | issue = 6 | pages = 918-925 | month = Dec | year = 2017 | doi = 10.1111/his.13311 | PMID = 28718911 }}</ref> | ||
*''Fuhrman grading'': | |||
**Older and more complicated. | |||
**Based on nuclear size and shape, chromatin pattern and [[nucleoli|nucleolar size]].<ref name=Ref_GUP282>{{Ref GUP|282}}</ref> | |||
==ISUP grading== | ==ISUP grading== | ||