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Difference between revisions of "Medulloblastoma"
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→IHC: Subgrouping
Jensflorian (talk | contribs) (→IHC: DDx) |
Jensflorian (talk | contribs) (→IHC: Subgrouping) |
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* Nestin +ve | * Nestin +ve | ||
* [[INI1]] retained (no loss) | * [[INI1]] retained (no loss) | ||
Genetic grouping with IHC:<ref>{{Cite journal | last1 = Pietsch | first1 = T. | last2 = Haberler | first2 = C. | title = Update on the integrated histopathological and genetic classification of medulloblastoma - a practical diagnostic guideline. | journal = Clin Neuropathol | volume = 35 | issue = 6 | pages = 344-352 | month = | year = | doi = 10.5414/NP300999 | PMID = 27781424 }}</ref> | |||
* WNT: beta-catein: nuclear +ve, YAP1+ve, OTX2+ve. | |||
* SHH: YAP1+ve, OTX2-ve, p75+ve. | |||
* Non-WNT/Non-SHH: * SHH: YAP1-ve, OTX2+ve, p75+ve. | |||
DDx: | DDx: | ||
*[[Small round cell tumours]]. | *[[Small round cell tumours]]. | ||
** [[AT/RT]] (INI1 loss) | ** [[AT/RT]] (INI1 loss) | ||
** CNS-[[PNET]] | ** CNS-embryonal tumour (aka CNS-[[PNET]]) | ||
** ETMR (LIN28)-positive | ** ETMR (LIN28)-positive | ||
** Ewing Sarcoma family members | ** Ewing Sarcoma family members | ||