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Difference between revisions of "Intraductal carcinoma of the prostate"
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Intraductal carcinoma of the prostate (view source)
Revision as of 21:21, 19 March 2018
, 21:21, 19 March 2018→Microscopic
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==Microscopic== | ==Microscopic== | ||
===Major criteria=== | ===Epstein criteria=== | ||
Epstein's IDCP criteria:<ref name=pmid16980940>{{Cite journal | last1 = Guo | first1 = CC. | last2 = Epstein | first2 = JI. | title = Intraductal carcinoma of the prostate on needle biopsy: Histologic features and clinical significance. | journal = Mod Pathol | volume = 19 | issue = 12 | pages = 1528-35 | month = Dec | year = 2006 | doi = 10.1038/modpathol.3800702 | PMID = 16980940 }}</ref> | |||
*"Large" acini or ducts with basal cells and one of the following: | |||
# Solid growth pattern or "dense" cribriform pattern. | |||
# Micropapillary pattern or "loose" cribriform pattern with one of the following: | |||
##Marked atypia 6x normal (area). | |||
##Non-focal comedonecrosis. | |||
===Shah criteria=== | |||
====Major criteria==== | |||
Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref><ref name=pmid17616999>{{Cite journal | last1 = Cohen | first1 = RJ. | last2 = Wheeler | first2 = TM. | last3 = Bonkhoff | first3 = H. | last4 = Rubin | first4 = MA. | title = A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 7 | pages = 1103-9 | month = Jul | year = 2007 | doi = 10.1043/1543-2165(2007)131[1103:APOTIH]2.0.CO;2 | PMID = 17616999 }}</ref> | Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref><ref name=pmid17616999>{{Cite journal | last1 = Cohen | first1 = RJ. | last2 = Wheeler | first2 = TM. | last3 = Bonkhoff | first3 = H. | last4 = Rubin | first4 = MA. | title = A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 7 | pages = 1103-9 | month = Jul | year = 2007 | doi = 10.1043/1543-2165(2007)131[1103:APOTIH]2.0.CO;2 | PMID = 17616999 }}</ref> | ||
#Glands 2x normal (peripheral zone) glands. | #Glands 2x normal (peripheral zone) glands. | ||
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*Comedo[[necrosis]]. | *Comedo[[necrosis]]. | ||
===Minor criteria=== | ====Minor criteria==== | ||
Minor criteria:<ref name=pmid22692290/> | Minor criteria:<ref name=pmid22692290/> | ||
#Branching of ducts at right angles. | #Branching of ducts at right angles. | ||
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#*Benign population (smaller nuclei, no nucleoli) = central location in gland. | #*Benign population (smaller nuclei, no nucleoli) = central location in gland. | ||
DDx | ===DDx=== | ||
*[[High-grade prostatic intraepithelial neoplasia]] (HGPIN). | *[[High-grade prostatic intraepithelial neoplasia]] (HGPIN). | ||
*Invasive [[prostate adenocarcinoma]]. | *Invasive [[prostate adenocarcinoma]]. | ||