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Difference between revisions of "P53"
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| Line 11: | Line 11: | ||
| Subspecial = | | Subspecial = | ||
| Pattern = | | Pattern = | ||
| Positive = nuclear staining | | Positive = nuclear staining | ||
| Negative = | | Negative = | ||
| Other = | | Other = | ||
}} | }} | ||
'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]]. | '''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]]. | ||
==Interpretation== | |||
*p53 may be one of the most misinterpreted stains. | |||
**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal | last1 = Yemelyanova | first1 = A. | last2 = Vang | first2 = R. | last3 = Kshirsagar | first3 = M. | last4 = Lu | first4 = D. | last5 = Marks | first5 = MA. | last6 = Shih | first6 = IeM. | last7 = Kurman | first7 = RJ. | title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1248-53 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.85 | PMID = 21552211 }}</ref> | |||
==See also== | ==See also== | ||