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| *[[AKA]] ''ovarian mucinous borderline tumour''. | | *[[AKA]] ''ovarian mucinous borderline tumour''. |
| *[[AKA]] ''ovarian mucinous tumour of low malignant potential''.<ref name=pmid21464732>{{Cite journal | last1 = Khunamornpong | first1 = S. | last2 = Settakorn | first2 = J. | last3 = Sukpan | first3 = K. | last4 = Suprasert | first4 = P. | last5 = Siriaunkgul | first5 = S. | title = Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. | journal = Int J Gynecol Pathol | volume = 30 | issue = 3 | pages = 218-30 | month = May | year = 2011 | doi = 10.1097/PGP.0b013e3181fcf01a | PMID = 21464732 }}</ref> | | *[[AKA]] ''ovarian mucinous tumour of low malignant potential''.<ref name=pmid21464732>{{Cite journal | last1 = Khunamornpong | first1 = S. | last2 = Settakorn | first2 = J. | last3 = Sukpan | first3 = K. | last4 = Suprasert | first4 = P. | last5 = Siriaunkgul | first5 = S. | title = Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. | journal = Int J Gynecol Pathol | volume = 30 | issue = 3 | pages = 218-30 | month = May | year = 2011 | doi = 10.1097/PGP.0b013e3181fcf01a | PMID = 21464732 }}</ref> |
| ===General===
| | {{Main|Mucinous borderline tumour of the ovary}} |
| *Requires extensive sampling - to avoid missing an adenocarcinoma.
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| Note:
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| *The WHO prefers ''borderline'' over ''low malignant potential'' as the descriptor for these tumours.<ref name=pmid16100867>{{Cite journal | last1 = Acs | first1 = G. | title = Serous and mucinous borderline (low malignant potential) tumors of the ovary. | journal = Am J Clin Pathol | volume = 123 Suppl | issue = | pages = S13-57 | month = Jun | year = 2005 | doi = | PMID = 16100867 }}</ref>
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| ====Classification====
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| Subdivided into:<ref name=pmid15371946>{{Cite journal | last1 = Rodriguez | first1 = IM. | last2 = Irving | first2 = JA. | last3 = Prat | first3 = J. | title = Endocervical-like mucinous borderline tumors of the ovary: a clinicopathologic analysis of 31 cases. | journal = Am J Surg Pathol | volume = 28 | issue = 10 | pages = 1311-8 | month = Oct | year = 2004 | doi = | PMID = 15371946 }}</ref>
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| # Intestinal type mucinous borderline tumour of the ovary ~ 90% of cases.
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| # Endocervical type mucinous borderline tumour of the ovary ~ 10% of cases.<ref name=Ref_GP419>{{Ref GP|419}}</ref>
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| ===Gross===
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| ''Intestinal type mucinous borderline tumour of the ovary'' and ''endocervical type mucinous borderline tumour of the ovary'':
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| *Complex multiloculated mass with mucin.
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| *Often large - may > 30 cm.
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| ===Microscopic===
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| ====Intestinal type mucinous borderline tumour of the ovary====
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| Features:
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| *Mucinous differentiation:
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| **Tall [[columnar cell]]s with apical mucin - usu. resembles gastric foveolar epithelium.
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| *Layering of epithelial cells (stratification).
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| **Must be <= 3 cells.<ref name=Ref_GP416>{{Ref GP|416}}</ref>
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| *+/-Papillary infoldings.
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| **Projections into the cystic space.
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| *+/-Mild nuclear atypia.
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| *+/-Mitoses (focally).
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| Notes:
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| #Resembles a [[villous adenoma]] of the [[colon]].<ref name=Ref_GP>{{Ref GP|416}}</ref>
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| #Borderline component must be >= 10% of the tumour.<ref name=Ref_GP>{{Ref GP|416}}</ref>
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| #*Lesions with <10% borderline component are known as ''[[mucinous cystadenoma of the ovary]] with focal proliferation'' or ''[[mucinous cystadenoma of the ovary]] with focal atypia''.
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| DDx:
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| *[[Mucinous adenocarcinoma of the ovary]].
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| *[[Mucinous cystadenoma of the ovary]].
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| *[[Mucinous cystadenoma of the ovary]] with focal proliferation.
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| Images:
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| *[http://www.webpathology.com/image.asp?case=526&n=7 Ovarian MBT (webpathology.com)].
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| *[http://www.webpathology.com/image.asp?n=6&Case=526 Ovarian mucinous borderline tumour and benign mucinous tumour (webpathology.com)].
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| ====Endocervical type mucinous borderline tumour of the ovary====
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| Features:<ref name=Ref_GP420>{{Ref GP|420}}</ref>
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| #Cells with mucinous differentiation resembling endocervical epithelium:
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| #*Tall [[columnar cell]]s with grey apical mucin.
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| #Cells with eosinophilic cytoplasm - known as "pink cells".
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| #Ciliated cells.
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| *Neutrophils associated with the epithelium/mucin - common.<ref>URL: [http://www.webpathology.com/image.asp?n=12&Case=526 http://www.webpathology.com/image.asp?n=12&Case=526]. Accessed on: 9 January 2013.</ref>
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| Images:
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| *[http://www.webpathology.com/image.asp?n=13&Case=526 Endocervical type mucinous borderline tumour - low mag. (webpathology.com)].
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| *[http://www.webpathology.com/image.asp?n=12&Case=526 Endocervical type mucinous borderline tumour - high mag. (webpathology.com)].
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| ====Comparing intestinal versus endocervical====
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| {| class="wikitable sortable"
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| ! Feature
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| ! Intestinal
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| ! Endocervical
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| |-
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| | Primary mucin producing cell
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| | clear - well-diff. component, eosinophilic (pink)
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| | eosinophilic (pink), grey or clear
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| |-
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| | Size
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| | tall columnar (height:width >3:1) "champagne flute"
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| | stubby columnar (height:width <3:1)
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| |-
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| | Accompanying epithelial cells
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| | +/-goblet cells
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| | pink cells, ciliated cells
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| |-
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| | Other cells
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| | none
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| | neutrophils (intraepithelial) - common
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| |-
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| | Images
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| | [http://www.webpathology.com/image.asp?case=526&n=7 high mag. (webpathology.com)]
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| | [http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]
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| |}
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| ===Sign out===
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| <pre>
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| OVARY AND CYST, LEFT, OOPHORECTOMY:
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| - MUCINOUS BORDERLINE TUMOUR, INTESTINAL TYPE, ARISING FROM A MUCINOUS CYSTADENOMA (INTESTINAL TYPE).
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| - OVARIAN PARENCHYMA.
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| </pre>
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|
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|
| ==Mucinous adenocarcinoma of the ovary== | | ==Mucinous adenocarcinoma of the ovary== |