Difference between pages "Neurothekeoma" and "Main Page"

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'''Neurothekeoma''' is a benign [[peripheral nerve sheath tumours|peripheral nerve sheath tumour]].
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It is also known as '''myxoma of the nerve sheath''' and '''nerve sheath myxoma'''.<ref name=pmid11070116>{{Cite journal  | last1 = Laskin | first1 = WB. | last2 = Fetsch | first2 = JF. | last3 = Miettinen | first3 = M. | title = The "neurothekeoma": immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. | journal = Hum Pathol | volume = 31 | issue = 10 | pages = 1230-41 | month = Oct | year = 2000 | doi = 10.1053/hupa.2000.18474 | PMID = 11070116 }}</ref>
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There is growing evidence that neurothekomas and dermal nerve sheath myxomas are distinct entities.<ref>{{Cite journal  | last1 = Sheth | first1 = S. | last2 = Li | first2 = X. | last3 = Binder | first3 = S. | last4 = Dry | first4 = SM. | title = Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. | journal = Mod Pathol | volume = 24 | issue = 3 | pages = 343-54 | month = Mar | year = 2011 | doi = 10.1038/modpathol.2010.203 | PMID = 21297585 }}</ref>
<div style="font-size:180%; text-align:center; border:none; padding:.1em">Welcome to [[Libre Pathology]]! A wiki looking for [[Libre Pathology:Contributing|contributors]]!</div>
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==General==
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*Rare.
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*Female > male.
<div style="font-size:150%; text-align:center; border:none; padding:.1em">''[[Libre Pathology news]]'': ''[[Libre Pathology:You can help Libre Pathology‎|You can help!]]''</div>
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==Microscopic==
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Features:<ref name=pmid17325474>{{cite journal |author=Hornick JL, Fletcher CD |title=Cellular neurothekeoma: detailed characterization in a series of 133 cases |journal=Am. J. Surg. Pathol. |volume=31 |issue=3 |pages=329–40 |year=2007 |month=March |pmid=17325474 |doi=10.1097/01.pas.0000213360.03133.89 |url=}}</ref>
{| class="wikitable" width=100%
*Superficial dermal lesion:
! scope="col" width="50%" | Weekly [[senior virtual case]]
**Usu. lobulated or micronodular architecture - '''key feature'''.
! scope="col" width="50%" | Weekly [[junior virtual case]]
***+/-Focal sheeting.
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**Spindle/epithelioid morphology with pale eosinophilic cytoplasm - '''key feature'''.
| [[Image:{{Main Page senior image}}|200px|link=http://librepathology.org/wiki/index.php/Case_{{Main Page senior case number}}|center|]]
**+/-Inflammation around lesion.
<center>[[Case {{Main Page senior case number}}|{{Main Page senior tease}}]]</center>  
**+/-Surrounded by collagen.


Notes:
| [[Image:{{Main Page junior image}}|200px|link=http://librepathology.org/wiki/index.php/Case_{{Main Page junior case number}}|center|]]
*No atypia.
<center>[[Case {{Main Page junior case number}}|{{Main Page junior tease}}]]</center>
*Mitoses rare/none.
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*Often poorly circumscribed.


Subtypes:<ref name=pmid10555009>{{cite journal |author=Wang AR, May D, Bourne P, Scott G |title=PGP9.5: a marker for cellular neurothekeoma |journal=Am. J. Surg. Pathol. |volume=23 |issue=11 |pages=1401–7 |year=1999 |month=November |pmid=10555009 |doi= |url=}}</ref>
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*Cellular.
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*[[Myxoid]].
! scope="col" width="50%" | The Collection
*Intermediate.
! scope="col" width="50%" | By Area
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| {{Collection}}
| {{Subspeciality}}
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DDx:
__NOTOC__
*[[Dermatofibroma]].
*[[Angiomatoid fibrous histiocytoma]] -- have cystic blood filled spaces, inflammation.<ref>URL: [http://surgpathcriteria.stanford.edu/softfib/angiomatoid_fibrous_histiocytoma/ http://surgpathcriteria.stanford.edu/softfib/angiomatoid_fibrous_histiocytoma/]. Accessed on: 11 May 2011.</ref>


===Images===
</div>
<gallery>
File:Neurothekeoma2.JPG | Neurothekeoma (WP)
</gallery>
====www====
*[http://path.upmc.edu/cases/case586.html Neurothekeoma - several images (upmc.edu)].
*[http://www.dermpedia.org/files/images/Image2_49.jpg Nerve sheath myxoma (dermpedia)]]
 
==IHC==
Features:<ref name=pmid17325474/>
*NKI/C3 ([[AKA]] NKI-C3) +ve.
*NSE +/-ve.
 
Others:<ref name=pmid17592278>{{cite journal |author=Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M |title=Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information |journal=Am. J. Surg. Pathol. |volume=31 |issue=7 |pages=1103–14 |year=2007 |month=July |pmid=17592278 |doi=10.1097/PAS.0b013e31802d96af |url=}}</ref>
*Vimentin +ve.
*CD10 +ve.
*Microphthalmia transcription factor +ve.
*PGP9.5 +ve.
 
Exclusionary:
*S100 -ve/+v3 (-ve in older literature).
**Myxoid variant +ve. {{fact}}
 
==See also==
*[[Peripheral nerve sheath tumours]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
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