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| ==Neurothekeoma== | | ==Neurothekeoma== |
| *[[AKA]] ''myxoma of the nerve sheath'', [[AKA]] ''nerve sheath myxoma''.
| | {{Main|Neurothekeoma}} |
| *There is growing evidence that neurothekomas and dermal nerve sheath myxomas are distinct entities.<ref>{{Cite journal | last1 = Sheth | first1 = S. | last2 = Li | first2 = X. | last3 = Binder | first3 = S. | last4 = Dry | first4 = SM. | title = Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. | journal = Mod Pathol | volume = 24 | issue = 3 | pages = 343-54 | month = Mar | year = 2011 | doi = 10.1038/modpathol.2010.203 | PMID = 21297585 }}</ref>
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| ===General===
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| *Rare.
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| *Female > male.
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| ===Microscopic===
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| Features:<ref name=pmid17325474>{{cite journal |author=Hornick JL, Fletcher CD |title=Cellular neurothekeoma: detailed characterization in a series of 133 cases |journal=Am. J. Surg. Pathol. |volume=31 |issue=3 |pages=329–40 |year=2007 |month=March |pmid=17325474 |doi=10.1097/01.pas.0000213360.03133.89 |url=}}</ref>
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| *Superficial dermal lesion:
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| **Usu. lobulated or micronodular architecture - '''key feature'''.
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| ***+/-Focal sheeting.
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| **Spindle/epithelioid morphology with pale eosinophilic cytoplasm - '''key feature'''.
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| **+/-Inflammation around lesion.
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| **+/-Surrounded by collagen.
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| Notes:
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| *No atypia.
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| *Mitoses rare/none.
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| *Often poorly circumscribed.
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| Subtypes:<ref name=pmid10555009>{{cite journal |author=Wang AR, May D, Bourne P, Scott G |title=PGP9.5: a marker for cellular neurothekeoma |journal=Am. J. Surg. Pathol. |volume=23 |issue=11 |pages=1401–7 |year=1999 |month=November |pmid=10555009 |doi= |url=}}</ref>
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| *Cellular.
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| *[[Myxoid]].
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| *Intermediate.
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| DDx:
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| *[[Dermatofibroma]].
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| *[[Angiomatoid fibrous histiocytoma]] -- have cystic blood filled spaces, inflammation.<ref>URL: [http://surgpathcriteria.stanford.edu/softfib/angiomatoid_fibrous_histiocytoma/ http://surgpathcriteria.stanford.edu/softfib/angiomatoid_fibrous_histiocytoma/]. Accessed on: 11 May 2011.</ref>
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| Images:
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| *[http://en.wikipedia.org/wiki/File:Neurothekeoma2.JPG Neurothekeoma (WP)].
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| *[http://path.upmc.edu/cases/case586.html Neurothekeoma - several images (upmc.edu)].
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| *[http://www.dermpedia.org/files/images/Image2_49.jpg Nerve sheath myxoma (dermpedia)]]
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| ===IHC===
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| Features:<ref name=pmid17325474/>
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| *NKI/C3 ([[AKA]] NKI-C3) +ve.
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| *NSE +/-ve.
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| Others:<ref name=pmid17592278>{{cite journal |author=Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M |title=Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information |journal=Am. J. Surg. Pathol. |volume=31 |issue=7 |pages=1103–14 |year=2007 |month=July |pmid=17592278 |doi=10.1097/PAS.0b013e31802d96af |url=}}</ref>
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| *Vimentin +ve.
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| *CD10 +ve.
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| *Microphthalmia transcription factor +ve.
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| *PGP9.5 +ve.
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| Exclusionary:
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| *S100 -ve.
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| **Exclude other peripheral nerve sheath tumours. (???)
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| **Myxoid variant +ve. {{fact}}
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| ==Malignant peripheral nerve sheath tumour== | | ==Malignant peripheral nerve sheath tumour== |