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Difference between revisions of "Immunohistochemical staining"
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Immunohistochemical staining (view source)
Revision as of 19:07, 8 January 2018
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In cases where the morphology is unclear, it is judicious to have two or more immunostains that support the diagnosis, and negative stains for important entities in the differential diagnosis. | In cases where the morphology is unclear, it is judicious to have two or more immunostains that support the diagnosis, and negative stains for important entities in the differential diagnosis. | ||
Publications with contradicting | Publications with contradicting results are not uncommon. Differences can arise from the fixation, processing protocol, antibody clone and interpretation. | ||
According to Galloway, one third pathologists substantially overestimate the diagnostic significance of unexpected immunohistochemical staining results.<ref name=pmid21660231>{{Cite journal | last1 = Galloway | first1 = M. | title = Base-rate error in the interpretation of immunohistochemistry. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 636495 | month = | year = 2011 | doi = 10.4061/2011/636495 | PMID = 21660231 }}</ref> | According to Galloway, one third pathologists substantially overestimate the diagnostic significance of unexpected immunohistochemical staining results.<ref name=pmid21660231>{{Cite journal | last1 = Galloway | first1 = M. | title = Base-rate error in the interpretation of immunohistochemistry. | journal = Patholog Res Int | volume = 2011 | issue = | pages = 636495 | month = | year = 2011 | doi = 10.4061/2011/636495 | PMID = 21660231 }}</ref> | ||