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Difference between revisions of "Thyroid gland"
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→Papillary thyroid carcinoma: more
(→Papillary thyroid carcinoma: more) |
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===Tall cell variant=== | ===Tall cell variant=== | ||
====General==== | ====General==== | ||
*~10% of PTC. | *~10% of PTC.<ref>{{Ref Sternberg5|505}}</ref> | ||
*Often large > 6 cm. | |||
====Microscopic==== | ====Microscopic==== | ||
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====Microscopic==== | ====Microscopic==== | ||
Features: | Features:<ref name=Ref_Sternberg5_506>{{Ref Sternberg5|506}}</ref> | ||
*Elongated nuclei (similar to colorectal adenocarcinoma) - '''key feature'''. | *Elongated nuclei (similar to colorectal adenocarcinoma) - '''key feature'''. | ||
*Pseudostratification of the nuclei (like in colorectal adenocarcinoma), differentiates from ''tall cell variant'' - '''key feature'''. | *+/-Pseudostratification of the nuclei (like in colorectal adenocarcinoma), differentiates from ''tall cell variant''. | ||
*Nuclear stratification - '''key feature'''. | |||
*"Minimal" papillary features. | *"Minimal" papillary features. | ||
*"Tall cells". | *"Tall cells". | ||
| Line 345: | Line 347: | ||
*Mitoses common. | *Mitoses common. | ||
Image: [http://www3.interscience.wiley.com/cgi-bin/fulltext/75000320/nfig003a?CRETRY=1&SRETRY=0 | Image: [http://www3.interscience.wiley.com/cgi-bin/fulltext/75000320/nfig003a?CRETRY=1&SRETRY=0 Columnar variant PTC (wiley.com)]. | ||
===Follicular variant=== | ===Follicular variant=== | ||
====General==== | ====General==== | ||
May be confused with follicular carcinoma or follicular adenoma. | *May be confused with follicular carcinoma or follicular adenoma. | ||
====Microscopic==== | ====Microscopic==== | ||
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*Prominent follicles. | *Prominent follicles. | ||
*Typically have less nuclear pseudoinclusions than the conventional type. | *Typically have less nuclear pseudoinclusions than the conventional type. | ||
*+/-Capsule. | |||
===Cribriform-morular variant=== | ===Cribriform-morular variant=== | ||
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DDx: | DDx: | ||
*Lymphocytic thyroiditis (esp. Hashimoto's thyroiditis). | *Lymphocytic thyroiditis (esp. Hashimoto's thyroiditis). | ||
===Warthin-like variant=== | |||
*Resemble [[Warthin tumour]]. | |||
====Microscopic==== | |||
Features:<ref name=Ref_Sternberg5_506>{{Ref Sternberg5|506}}</ref> | |||
*Eosinophilic cytoplasm. | |||
*Lymphocytic thyroiditis. | |||
*Papillae. | |||
==Insular carcinoma== | ==Insular carcinoma== | ||