Account-creators
1,040
edits
Difference between revisions of "Ganglioglioma"
Jump to navigation
Jump to search
→Microscopic
Jensflorian (talk | contribs) (update) |
Jensflorian (talk | contribs) |
||
| Line 63: | Line 63: | ||
**Clustering | **Clustering | ||
**Binucleated (very occassionally). | **Binucleated (very occassionally). | ||
*Atypical glia. | *Atypical glia (ie neoplastic). | ||
*Eosinophilic granular bodies. | *Eosinophilic granular bodies (more common than rosenthal fibers). | ||
* | *Dystrophic calcification. | ||
*Prominent capillary network. | *Prominent capillary network. | ||
*Lymphocytic cuffing. | *Lymphocytic cuffing. | ||
| Line 83: | Line 83: | ||
**Synaptophysin +ve | **Synaptophysin +ve | ||
** Neurofilament +ve | ** Neurofilament +ve | ||
** Chromogranin +ve | |||
*Glia: | *Glia: | ||
**CD34+/-ve | **CD34+/-ve | ||
*BRAF V600E +ve (approx. 25%, mainly ganglion cells). | *BRAF V600E +ve (approx. 25%, mainly ganglion cells). | ||
*MAP2: usu. absent. | |||
*MIB-1 (low, but resembles proliferative tumor component). | |||
====Molecular==== | ====Molecular==== | ||
*BRAF V600E-mutated(approx. 25%). | *BRAF V600E-mutated(approx. 25%). | ||
**BRAF V600E antibody stains especially neuronal cells. | |||
*IDH1/2 wt. | *IDH1/2 wt. | ||
*No 1p/19q codeletion. | *No 1p/19q codeletion. | ||