Difference between revisions of "Neuropathology"

Jump to navigation Jump to search

Neuropathology (view source)

Revision as of 14:55, 18 August 2017

2,456 bytes removed ,  14:55, 18 August 2017
→‎Central pontine myelinolysis: rename - split out
(→‎Vasculitis: GCA added)
(→‎Central pontine myelinolysis: rename - split out)
Line 835: Line 835:




===Central pontine myelinolysis===
===Osmotic demyelination syndrome===
*Abbreviated ''CPM''.
{{Main|Osmotic demyelination syndrome}}
*[[AKA]] ''pontine myelinolysis''.
*Previously known as ''central pontine myelinolysis'' (abbreviated ''CPM'').
 
General:
*Classically in the pons, ergo "pontine" is in the name.
*Classically midline, ergo "central" is in the name.
**May occur elsewhere -- known as ''extrapontine myelinolysis''.
 
Etiology:
*Rapid correction of hyponatremia.<ref name=pmid22080394>{{Cite journal  | last1 = Chang | first1 = Y. | last2 = An | first2 = DH. | last3 = Xing | first3 = Y. | last4 = Qi | first4 = X. | title = Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction. | journal = Neurol Sci | volume =  | issue =  | pages =  | month = Nov | year = 2011 | doi = 10.1007/s10072-011-0838-3 | PMID = 22080394 }}</ref>
*Tacrolimus post-liver transplant.<ref name=pmid21959523>{{Cite journal  | last1 = Fukazawa | first1 = K. | last2 = Nishida | first2 = S. | last3 = Aguina | first3 = L. | last4 = Pretto | first4 = E. | title = Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation. | journal = Ann Transplant | volume = 16 | issue = 3 | pages = 139-42 | month = Sep | year = 2011 | doi =  | PMID = 21959523 }}</ref>
*Associated with [[alcoholism]] and malnourishment.
 
Clinical:<ref>{{Cite journal  | last1 = Lai | first1 = CC. | last2 = Tan | first2 = CK. | last3 = Lin | first3 = SH. | last4 = Chen | first4 = HW. | title = Central pontine myelinolysis. | journal = CMAJ | volume = 183 | issue = 9 | pages = E605 | month = Jun | year = 2011 | doi = 10.1503/cmaj.090186 | PMID = 21543311 | PMC = 3114939 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114939/?tool=pubmed }}</ref>
*Decreased level of consciousness - most common.
*Quadriplegia.
*Poor prognosis.
 
Microscopic:
Features:<ref name=npw_ch6>URL: [http://neuropathology-web.org/chapter6/chapter6dCPM.html http://neuropathology-web.org/chapter6/chapter6dCPM.html]. Accessed on: 20 December 2011.</ref>
*Myelin loss.
*No inflammation.
*Relative preservation of neurons.
 
<gallery>
File:Pontine myelinolysis.jpg | Luxol fast blue (LFB stain) in a case of central pontine myelinolysis (WC/jensflorian)
File:Pontine myelinolysis myelinophages.jpg | Myelinophages in CPM showing intracellular myelin fragments (WC/jensflorian)
</gallery>
 
Images:
*[http://neuropathology-web.org/chapter6/images6/6-9l.jpg CPM (neuropathology-web.org)].<ref name=npw_ch6>URL: [http://neuropathology-web.org/chapter6/chapter6dCPM.html http://neuropathology-web.org/chapter6/chapter6dCPM.html]. Accessed on: 20 December 2011.</ref>
*[http://dartmed.dartmouth.edu/spring09/html/virtual_microscopy_we/ CPM (dartmouth.edu)].


===Acute disseminated encephalomyelitis===
===Acute disseminated encephalomyelitis===
Michael
48,436

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/47768"

Navigation menu