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==Brown cell tumour== | ==Brown cell tumour== | ||
=== | ===General=== | ||
*''Not'' a true neoplasm,<ref name=pmid16775919>{{cite journal |author=Meydan N, Barutca S, Guney E, ''et al.'' |title=Brown tumors mimicking bone metastases |journal=J Natl Med Assoc |volume=98 |issue=6 |pages=950–3 |year=2006 |month=June |pmid=16775919 |pmc=2569361 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569361/?page=1 }}</ref> i.e. the name is a misnomer. | |||
**May (clinically) mimic a true neoplasm. | |||
*Due to hyperparathyroidism - usually parathyroid adenoma. | *Due to hyperparathyroidism - usually parathyroid adenoma. | ||
**Usually secondary to chronic renal failure. | **Usually secondary to chronic renal failure. | ||
= | ====Hypercalcemia DDx==== | ||
===Hypercalcemia DDx=== | |||
Mnemonic ''GRIMED'':<ref>TN06 Emerg.</ref> | Mnemonic ''GRIMED'':<ref>TN06 Emerg.</ref> | ||
*Granulomatous disease (tuberculosis, [[sarcoidosis]]). | *Granulomatous disease (tuberculosis, [[sarcoidosis]]). | ||
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*Endocrine (primary hyperparathyroidism - leads to brown cell tumour). | *Endocrine (primary hyperparathyroidism - leads to brown cell tumour). | ||
*Drugs (thiazides ... others). | *Drugs (thiazides ... others). | ||
===Microscopy=== | |||
Features: | |||
*Fibrosis. | |||
*+/-Giant cells. | |||
DDx: | |||
*[[Giant cell tumour of bone]]. | |||
==Giant cell tumour of bone== | ==Giant cell tumour of bone== |
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