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Difference between revisions of "Fulminant hepatic necrosis"
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→Microscopic
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid18771870/> | ||
*Hepatocyte [[necrosis]]. | *Hepatocyte [[necrosis]] - '''key feature'''. | ||
*Bile duct proliferation. | *Bile duct proliferation. | ||
*Inflammatory cell infiltrate. | |||
DDx: | DDx: | ||
*[[Cholangiocarcinoma]]. | *[[Cholangiocarcinoma]]. | ||
*[[Angiosarcoma]]. | *[[Angiosarcoma]]. | ||
*Necrotic [[metastasis|metastatic]] tumour. | |||
===Images=== | ===Images=== | ||
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F. [[File:6 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]] | F. [[File:6 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]] | ||
<br> | <br> | ||
Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis. | Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis. | ||
==See also== | ==See also== | ||