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Difference between revisions of "Clear cell acanthoma"
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'''Clear cell acanthoma''', abbreviated '''CCA''', a [[Non-malignant_skin_disease|benign]] skin lesion classically found on the leg. | |||
==General== | |||
*Benign. | |||
*Elderly. | |||
*Classically on the leg.<ref name=pmid18583817>{{Cite journal | last1 = Akin | first1 = FY. | last2 = Ertam | first2 = I. | last3 = Ceylan | first3 = C. | last4 = Kazandi | first4 = A. | last5 = Ozdemir | first5 = F. | title = Clear cell acanthoma: new observations on dermatoscopy. | journal = Indian J Dermatol Venereol Leprol | volume = 74 | issue = 3 | pages = 285-7 | month = | year = | doi = | PMID = 18583817 | URL = http://www.ijdvl.com/text.asp?2008/74/3/285/41396 }}</ref> | |||
*Rare. | |||
*Clinically not distinct. | |||
**Suspected clinically in only ~3% of cases.<ref name=pmid20931670>{{Cite journal | last1 = Morrison | first1 = LK. | last2 = Duffey | first2 = M. | last3 = Janik | first3 = M. | last4 = Shamma | first4 = HN. | title = Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. | journal = Int J Dermatol | volume = 49 | issue = 9 | pages = 1008-11 | month = Sep | year = 2010 | doi = | PMID = 20931670 }}</ref> | |||
==Microscopic== | |||
Features:<ref>URL: [http://www.drmihm.com/cases/case.cfm?CaseID=45 http://www.drmihm.com/cases/case.cfm?CaseID=45]. Accessed on: 7 February 2012.</ref> | |||
*Psoriasiform pattern - epidermal thickening ([[acanthosis]]). | |||
*Keratinocytes: | |||
**Pale or light pink cytoplasm (when compared to surrounding non-lesional keratinocytes). | |||
**Separated from one another (spongiosis). | |||
*+/-Stratum corneum [[neutrophil]]s. | |||
DDx: | |||
*[[Psoriasis vulgaris]]. | |||
*[[Bowen's disease]]. | |||
*[[Poroma]]. | |||
*[[Seborrehic keratosis]]. | |||
===Images=== | |||
*[http://www.drmihm.com/cases/casefigure.cfm?figID=906&CaseID=45 CCA (drmihm.com)]. | |||
*[http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-327718365 CCA - low mag. (dermatlas.com)]. | |||
*[http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=546460717 CCA - high mag. (dermatlas.com)]. | |||
==See also== | |||
*[[Non-malignant skin disease]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Non-malignant skin disease]] | |||