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Difference between revisions of "Small round cell tumours"
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IHC table
(→Tabular comparison: tweak) |
(IHC table) |
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| [[Nephroblastoma]] (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| '''triphasic''' - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | | '''triphasic''' - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | ||
| kidney lesion, various syndromes | | kidney lesion, various syndromes (e.g. Beckwith-Wiedemann syndrome<ref>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002168/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002168/]. Accessed on: 4 April 2011.</ref>) | ||
| WT-1+ | | WT-1+ | ||
|- | |- | ||
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| [[Medulloblastoma]] | | [[Medulloblastoma]] | ||
| '''Homer-Wright rosettes''' ([[rosette]] with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | | '''Homer-Wright rosettes''' ([[rosette]] with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
| +/-[[nevoid basal cell carcinoma syndrome]] | | +/-[[nevoid basal cell carcinoma syndrome]]; '''must''' arise in cerebellum | ||
| | | | ||
|- | |- | ||
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|- | |- | ||
| [[Alveolar rhabdomyosarcoma]] | | [[Alveolar rhabdomyosarcoma]] | ||
| '''alveolar-like spaces''' (small blue cells line spaces supported by fibrous tissue), | | '''alveolar-like spaces''' (small blue cells line spaces supported by fibrous tissue), rhabdomyoblasts (eosinophilic cytoplasm, +/-cross striations (uncommon), eccentric nucleus, +/-elongated/cigar-shaped cells (uncommon)) | ||
| adolescents, young adults; often mets at presentation | | adolescents, young adults; often mets at presentation | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | | [[Embryonal rhabdomyosarcoma]]<sup>§</sup> | ||
| '''nests with rounded border''', | | '''nests with rounded border''', rhabdomyoblasts (+/-elongated/cigar-shaped cells, eosinophilic cytoplasm, +/-cross striations, eccentric nucleus) | ||
| <10 years old; usu. localized | | <10 years old; usu. localized | ||
| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
| Line 90: | Line 90: | ||
Notes: | Notes: | ||
*<sup>§</sup> Uncommonly has the small round cell tumour morphology - included for comparison to ''[[alveolar rhabdomyosarcoma]]''. | *<sup>§</sup> Uncommonly has the small round cell tumour morphology - included for comparison to ''[[alveolar rhabdomyosarcoma]]''. | ||
==IHC panel== | |||
Gino's panel:<ref>GS. 22 March 2011.</ref> | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
! Lesion | |||
! NB84 | |||
! Myogenin | |||
! Desmin | |||
! CD99 | |||
! CD45 | |||
|- | |||
| Lymphoma | |||
| -ve | |||
| -ve | |||
| -ve | |||
| +ve/-ve | |||
| + | |||
|- | |||
| Ewing sarcoma | |||
| +ve/-ve | |||
| -ve | |||
| -ve | |||
| +ve (membranous) | |||
| - | |||
|- | |||
| Neuroblastoma | |||
| +ve | |||
| -ve | |||
| -ve | |||
| +ve/-ve | |||
| -ve | |||
|- | |||
| Rhabdomyosarcoma | |||
| -ve | |||
| +ve | |||
| +ve | |||
| -ve | |||
| -ve | |||
|} | |||
==See also== | ==See also== | ||