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Difference between revisions of "Melanotic Xp11 translocation renal cancer"
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Melanotic Xp11 translocation renal cancer (view source)
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'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref>{{Cite journal | last1 = Rao | first1 = Q. | last2 = Shen | first2 = Q. | last3 = Xia | first3 = QY. | last4 = Wang | first4 = ZY. | last5 = Liu | first5 = B. | last6 = Shi | first6 = SS. | last7 = Shi | first7 = QL. | last8 = Yin | first8 = HL. | last9 = Wu | first9 = B. | title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. | journal = Am J Surg Pathol | volume = 39 | issue = 9 | pages = 1181-96 | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000502 | PMID = 26274027 }}</ref> | '''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref name=pmid26274027>{{Cite journal | last1 = Rao | first1 = Q. | last2 = Shen | first2 = Q. | last3 = Xia | first3 = QY. | last4 = Wang | first4 = ZY. | last5 = Liu | first5 = B. | last6 = Shi | first6 = SS. | last7 = Shi | first7 = QL. | last8 = Yin | first8 = HL. | last9 = Wu | first9 = B. | title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. | journal = Am J Surg Pathol | volume = 39 | issue = 9 | pages = 1181-96 | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000502 | PMID = 26274027 }}</ref> | ||
==General== | |||
*Evolving entity.<ref name=pmid19065101>{{Cite journal | last1 = Argani | first1 = P. | last2 = Aulmann | first2 = S. | last3 = Karanjawala | first3 = Z. | last4 = Fraser | first4 = RB. | last5 = Ladanyi | first5 = M. | last6 = Rodriguez | first6 = MM. | title = Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 609-19 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818fbdff | PMID = 19065101 }}</ref><ref name=pmid26274027/> | |||
*Very rare. | |||
==Microscopic== | |||
Features: | |||
*Melanin-like pigment. | |||
*Clear cells, epithelioid morphology - similar to [[Xp11.2 translocation carcinoma]]. | |||
DDx: | |||
*[[PEComa]] - may have TFE3 rearrangement. | |||
*[[Malignant melanoma]]. | |||
*[[Xp11.2 translocation carcinoma]]. | |||
==IHC== | |||
*TFE3 +ve. | |||
*Keratin -ve. | |||
==Molecular== | |||
*TFE3 rearrangement. | |||
==See also== | ==See also== | ||