Difference between revisions of "Meningioma"

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SSTr2A DDx
(SSTr2A DDx)
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===DDx of meningioma & IHC<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref>===
===DDx of meningioma & IHC<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref>===
*S-100 +ve - [[schwannoma]].
*S-100 strong +ve - [[schwannoma]].
**+ve in ~80% of fibrous meningiomas.
**+ve in ~80% of fibrous meningiomas.
*CD34 +ve - [[solitary fibrous tumour]].
*CD34 +ve - [[solitary fibrous tumour]].
**+ve in ~60% of [[fibrous meningioma]]s.
**+ve in ~60% of [[fibrous meningioma]]s.
*STAT6 nuclear +ve: [[solitary fibrous tumour]].
*STAT6 nuclear +ve: [[solitary fibrous tumour]].
*[[EMA]] +ve in ~30% of hemangiopericytoma.
*[[EMA]] +ve in ~30% of [[solitary fibrous tumour]]/[[hemangiopericytoma]].
*Claudin-1 - new kid on the block: +ve in meningioma, but low [[sensitivity]].
*Claudin-1 - new kid on the block: +ve in meningioma, but low [[sensitivity]].
*SSTR2A +ve in meningioma, usu. -ve in [[Perineurioma]] <ref>{{Cite journal  | last1 = Agaimy | first1 = A. | last2 = Buslei | first2 = R. | last3 = Coras | first3 = R. | last4 = Rubin | first4 = BP. | last5 = Mentzel | first5 = T. | title = Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. | journal = Histopathology | volume = 65 | issue = 1 | pages = 60-70 | month = Jul | year = 2014 | doi = 10.1111/his.12366 | PMID = 24393170 }}</ref>
* Progesterone receptor: +ve in mostly grade I and meningeothelial tumors.<ref>{{Cite journal  | last1 = Grunberg | first1 = SM. | title = The role of progesterone receptors in meningioma. | journal = Cancer Treat Res | volume = 58 | issue =  | pages = 127-37 | month =  | year = 1991 | doi =  | PMID = 1683782 }}</ref>
* Progesterone receptor: +ve in mostly grade I and meningeothelial tumors.<ref>{{Cite journal  | last1 = Grunberg | first1 = SM. | title = The role of progesterone receptors in meningioma. | journal = Cancer Treat Res | volume = 58 | issue =  | pages = 127-37 | month =  | year = 1991 | doi =  | PMID = 1683782 }}</ref>
* [[Pulmonary meningothelial-like nodule]]
* [[Pulmonary meningothelial-like nodule]]
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