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Difference between revisions of "Basics"
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→Basic pathologic DDx of malignancy: cohesive vs. dyscohesive
(+link to granuloma atlas) |
(→Basic pathologic DDx of malignancy: cohesive vs. dyscohesive) |
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*''Lymphoma'' includes leukemia. | *''Lymphoma'' includes leukemia. | ||
===Morphologic grouping=== | |||
Factors to consider when attempting to group by morphology: | Factors to consider when attempting to group by morphology: | ||
#Cell cohesion - dyscohesive vs. cohesive. | #Cell cohesion - dyscohesive vs. cohesive. | ||
| Line 79: | Line 80: | ||
*Lymphoma = dyscohesive, relatively small (usually <=2X neutrophil diameter), usu. scant basophilic (blue) cytoplasm. | *Lymphoma = dyscohesive, relatively small (usually <=2X neutrophil diameter), usu. scant basophilic (blue) cytoplasm. | ||
*Melanoma = classically pigmented, often a prominent red nucleolus, a mix of spindle cells and epithelioid cells, mix of cohesive and dyscohesive cells. | *Melanoma = classically pigmented, often a prominent red nucleolus, a mix of spindle cells and epithelioid cells, mix of cohesive and dyscohesive cells. | ||
====Dyscohesive vs. cohesive==== | |||
Deciding cells are dyscohesive vs. cohesive is important, as it is a strong determinant of whether one is dealing with a lymphoid lesion or not. | |||
{| class="wikitable" | |||
!| | |||
!| Cell spacing | |||
!| Cell membrane | |||
!| Cytoplasm, abundance | |||
!| Cytoplasm, staining | |||
|- | |||
| '''Cohesive''' | |||
| equal or 3-D clusters | |||
| visible, opposed in >50% of cells | |||
| scant to abundant | |||
| any | |||
|- | |||
| '''Dyscohesive''' | |||
| unequal | |||
| not apparent | |||
| usually scant | |||
| usually basophilic | |||
|- | |||
| Value | |||
| equal or 3-D clusters r/i cohesive | |||
| visible opposed membrane r/i cohesive | |||
| abundant usu. cohesive | |||
| eosinophilic usu. cohesive | |||
|} | |||
===Histomorphologic classification=== | ===Histomorphologic classification=== | ||