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Difference between revisions of "Neurodegenerative diseases"
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→Parkinson disease: tweak, + clinical
(→Parkinson disease: tweak) |
(→Parkinson disease: tweak, + clinical) |
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===General=== | ===General=== | ||
*Common. | *Common. | ||
Clinical ''TRAP'':<ref>URL: [http://www.nysslha.org/i4a/pages/index.cfm?pageid=3519 http://www.nysslha.org/i4a/pages/index.cfm?pageid=3519]. Accessed on: 30 March 2011.</ref> | |||
*Tremor. | |||
*Rigidity. | |||
*Akinesia. | |||
*Postural instability. | |||
===Gross=== | ===Gross=== | ||
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*Loss of pigmented (catecholaminergic) neurons in the substantia nigra. | *Loss of pigmented (catecholaminergic) neurons in the substantia nigra. | ||
*Gliosis - due to neuron loss. | *Gliosis - due to neuron loss. | ||
*Lewy bodies (in remaining neurons) - '''key feature'''. | |||
**Eosinophilic cytoplasmic inclusion with "dense" (darker) core and pale (surrounding) halo. | |||
***Consist of filaments composed of alpha-synuclein. | |||
===IHC=== | |||
*Alpha-synuclein +ve. | |||
==Prion diseases== | ==Prion diseases== | ||