Difference between revisions of "ELOC-mutated renal cell carcinoma"

ELOC-mutated renal cell carcinoma (view source)

4 bytes removed , 19:48, 28 February 2017

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 ===Molecular lacking===
 <pre>
-Left Kidney, Partial Nephrectomy:
+Right Kidney, Radical Nephrectomy:
-- Renal cell carcinoma (RCC) with clear cells and leiomyomatous stroma,
+     - CLEAR CELL RENAL CELL CARCINOMA with cysts and leiomyomatous
-  favour clear cell RCC, see comment.
+        stroma, see comment.
-- ISUP nucleolar grade 2/4.
+     -- Margin clear.
-- TMN stage: pT1a pNx
+     -- Please see synoptic report for details.
-- Please see synoptic report.
 Comment:
 The tumour stains as follows:
-POSITIVE: CK7, CD10.
+POSITIVE: CD10 (moderate), EMA (patchy), CAM5.2, CK7 (focal), PAX8 (diffuse).
-NEGATIVE: CK34betaE12, CD34, CK20.
+NEGATIVE: CK34betaE12, CK20.
 The staining and morphology raises the possibility of a TCEB-1 mutation, described
-in a subset of clear cell RCC.
+in a subset of clear cell renal cell carcinoma.[1]
-The differential diagnosis includes clear cell renal cell carcinoma and clear cell
+. Mod Pathol 28 (6): 845-53. doi:10.1038/modpathol.2015.6. PMID 25676555.
-papillary RCC.  Clear cell RCC is favoured.
 </pre>