Difference between revisions of "Medical liver disease"

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===Microscopic===
===Microscopic===
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[[File:1 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
A. [[File:1 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
[[File:2 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
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[[File:3 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
B. [[File:2 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
[[File:4 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
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[[File:5 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
C. [[File:3 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
[[File:6 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
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D. [[File:4 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. Pink preserved parenchyma strews empty necrotic spaces (Row 1 Left 20X). Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver (Row 1 Right 200X). Iron stain shows the macrophages bear hemosiderin (Row 2 Left 200X). Reticulin stain highlights the recently dead liver cells (Row 2 Right 200X). Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge (Row 3 Left 200X).   Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis (Row 3 Right 200X).  
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E. [[File:5 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
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F. [[File:6 Necrosis 2 680x512px.tif| Submassive hepatic necrosis.]]
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Submassive hepatic necrosis. Patient had transaminases in the thousands that rapidly dropped to normal. A/ Pink preserved parenchyma strews empty necrotic spaces. B. Focus of necrosis with no apparent hepatocytes macrophages abuts apparently normal liver. C. Iron stain shows the macrophages bear hemosiderin. D. Reticulin stain highlights the recently dead liver cells. E. Reticulin stain shows a necrotic bridge forming; the multiple small black circles preclude diagnosis of a fibrous bridge. F. Trichrome shows the necrotic bridge (“collapse”) lacks much collagen deposition, as would be expected for bridging fibrosis.  


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