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Difference between revisions of "Neuropathology"
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→Acute disseminated encephalomyelitis: rework
(→Multiple sclerosis: more) |
(→Acute disseminated encephalomyelitis: rework) |
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| Line 532: | Line 532: | ||
*Abbreviated "ADEM". | *Abbreviated "ADEM". | ||
Treatment: | |||
*Steroids. | |||
*Plasmapheresis. | |||
Diagnosis: | |||
*Need to r/o infection (with lumbar puncture). | *Need to r/o infection (with lumbar puncture). | ||
*No old plaques on imaging (MRI). | *No old plaques on imaging (MRI). | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref>{{Ref PBoD8|1312}}</ref> | ||
* | *Myelin loss with sparing of axons. | ||
*Inflammation: | |||
**Early: neutrophils. | |||
* | **Late: mononuclear cells (lymphocytes, plasma cells). | ||
* | *Lipid-laden macrophages. | ||
DDx | |||
*Multiple sclerosis. | *Multiple sclerosis. | ||
**Age of lesions differs. | |||
*Acute necrotizing hemorrhagic encephalomyelitis (ANHE). | |||
==Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)== | ==Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)== | ||