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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | #Morphologic changes - memory device ''ABCDEF'': | ||
#*'''A'''typia minimal - usually. | |||
#**Relatively small ~1-2x size lymphocyte. | |||
#*'''B'''orders of cells distinct/visible - ''dyscohesive''. | |||
#*'''C'''lear cytoplasm (focal). | |||
#**May have a signet ring cell-like appearance. | |||
#*'''D'''istend duct. | |||
#*'''E'''ccentric nucleus, usu. round. | |||
#*'''F'''illed ducts. | |||
#**'''No''' luminal spaces - '''key feature'''. | |||
#***Partially filled ducts are ''not'' LCIS. | |||
#Limited extent: <50% of terminal duct lobular unit (TDLU) is involved. | |||
DDx: | DDx: |
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