Difference between revisions of "Extramammary Paget disease"

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***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile.
***Pagetoid squamous cell carcinoma in situ can lose HMW keratins and produce a LMW profile.
**Adenocarcinoma markers? - CEA, BerEP4
**Adenocarcinoma markers? - CEA, BerEP4
**Nuclear differentiation markers? - p63 or p40 (squamous) vs GATA3 (adnexal)
**Nuclear differentiation markers? - p63 or [[p40]] (squamous) vs GATA3 (adnexal)
*Is the lesion primary or secondary?
*Is the lesion primary or secondary?
**Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal)
**Secondary extramammary Paget disease may be CK20 positive (urothelial or rectal)
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