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Cutaneous T-cell lymphoma (view source)
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'''Cutaneous_T-cell lymphoma''', abbreviated '''CTCL''', is a malignant [[dermatologic neoplasms|neoplasm that arises in the skin]]. | |||
==General== | |||
*''Mycosis fungoides'' - is a subtype (???). | |||
*CTCL is more common than cutaneous B-cell lymphoma (CBCL).<ref>URL: [http://emedicine.medscape.com/article/1099540-overview http://emedicine.medscape.com/article/1099540-overview]. Accessed on: 24 August 2010.</ref><ref>URL: [http://emedicine.medscape.com/article/1098342-overview http://emedicine.medscape.com/article/1098342-overview]. Accessed on: 24 August 2010.</ref> | |||
Stages - like [[Kaposi sarcoma]]: | |||
*Patch. | |||
*Plaque. | |||
*Nodular. | |||
==Microscopic== | |||
*Atypical lymphocytes: | |||
**Have folded "cerebriform" nuclei; ''Sezary-Lutzner cells''.<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref> | |||
*Grouping: | |||
**Nests in the epidermis - known as "Pautrier microabscesses". | |||
**Single lymphocytes in epidermis - without accompanying edema. | |||
**Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref> | |||
DDx: | |||
*[[Lymphomatoid papulosis]]. | |||
===Images=== | |||
<gallery> | |||
Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg | CTCL - very high mag. (WC/Nephron) | |||
Image:Cutaneous_T-cell_lymphoma_-_intermed_mag.jpg | CTCL - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.jci.org/articles/view/24826/figure/2 CTCL (jci.org)]. | |||
*[http://www.mdconsult.com/das/book/body/199872830-2/0/1709/I4-u1.0-B978-0-443-06694-8..50117-2--f2.fig CTCL (mdconsult.com)]. | |||
==IHC== | |||
Key stain: | |||
*CD4 +ve.<ref>{{Ref PBoD8|1185}}</ref> | |||
Other stains: | |||
*CD3 +ve. | |||
*CD8 -ve. | |||
*CD20 -ve (to r/o significant B cell population). | |||
*CD30 -ve. | |||
*CD5 +ve. | |||
*CD7 -ve (often lost first in T cell lymphomas). | |||
*Ki-67 high. | |||
*CD56 -ve. | |||
==See also== | |||
*[[Dermatologic neoplasms]] | |||
*[[Lymphoma]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Dermatopathology]] | |||
[[Category:Hematopathology]] | |||