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Atypical lobular hyperplasia (view source)
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'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the breast characterized cellular proliferation and cellular dyscohesion. | |||
It can be seen as the pre-cursor to the pre-cursor ([[lobular carcinoma in situ]]). | |||
==General== | |||
*May occur with ''ductal involvement by cells of atypical lobular hyperplasia'' (abbreviated ''DIALH'').<ref name=pmid3343034>{{Cite journal | last1 = Page | first1 = DL. | last2 = Dupont | first2 = WD. | last3 = Rogers | first3 = LW. | title = Ductal involvement by cells of atypical lobular hyperplasia in the breast: a long-term follow-up study of cancer risk. | journal = Hum Pathol | volume = 19 | issue = 2 | pages = 201-7 | month = Feb | year = 1988 | doi = | PMID = 3343034 }}</ref> | |||
**ALH with DIALH has a risk of developing breast cancer that is similar to [[LCIS]]. | |||
==Microscopic== | |||
Features: | |||
*Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved. | |||
*See ''[[lobular carcinoma in situ]]'' for details. | |||
DDx: | |||
*[[Lobular carcinoma in situ]]. | |||
*[[Lobular carcinoma]]. | |||
==IHC== | |||
*E-cadherin -ve ''or'' incomplete membrane staining. | |||
==See also== | |||
*[[Non-invasive breast carcinoma]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||