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Difference between revisions of "Hepatitis C"
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→Microscopic: a case with severe disease and mild fibrosis
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Hepatitis C. Metavir Activity Index 2 (PMN2, LN1), Metavir fibrosis stage 3. | Hepatitis C. Metavir Activity Index 2 (PMN2, LN1), Metavir fibrosis stage 3. | ||
Expanded dark triads, indicating interface hepatitis [red arrows], foci of steatosis [green arros], potential bridge [blue arrow] (Row 1 Left 20X). Extending from triad are stretches of apparent necrosis [green arrows], inflammatory cells bound hepatocytes afflicted by piecemeal necrosis [yellow arrows], ballooning degeneration denoted by cytoplasmic tufts [blue arrows] (Row 1 Right 400X). Reticulin shows collapse (necrosis) with thick bands [red arrows], as well as rosettes [green arrows] indicating dilated cholangioles (Row 2 Left 200X). Reticulin here shows continuous piecemeal necrosis with black bounded hepatocyte islets [arrows] (Row 2 Right 200X). Reticulin here shows a bridge with regeneration, wherein two or more nuclei lie between reticulin lines [arrows] (Row 3 Left 200X). Trichrome demarcates one of the bridges (Row 3 Right 200X). | Expanded dark triads, indicating interface hepatitis [red arrows], foci of steatosis [green arros], potential bridge [blue arrow] (Row 1 Left 20X). Extending from triad are stretches of apparent necrosis [green arrows], inflammatory cells bound hepatocytes afflicted by piecemeal necrosis [yellow arrows], ballooning degeneration denoted by cytoplasmic tufts [blue arrows] (Row 1 Right 400X). Reticulin shows collapse (necrosis) with thick bands [red arrows], as well as rosettes [green arrows] indicating dilated cholangioles (Row 2 Left 200X). Reticulin here shows continuous piecemeal necrosis with black bounded hepatocyte islets [arrows] (Row 2 Right 200X). Reticulin here shows a bridge with regeneration, wherein two or more nuclei lie between reticulin lines [arrows] (Row 3 Left 200X). Trichrome demarcates one of the bridges (Row 3 Right 200X).<br> | ||
[[File:HCV MAI 3 st 1.png|33.589444 101.891944]] | |||
[[File:HCV MAI 3 st 2.png|33.589444 101.891944]] | |||
[[File:HCV MAI 3 st 3.png|33.589444 101.891944]] | |||
[[File:HCV MAI 3 st 4.png|33.589444 101.891944]] | |||
[[File:HCV MAI 3 st 5.png|33.589444 101.891944]] | |||
Hepatitis C virus. Metavir activity index 3. Metavir fibrosis stage 1. A. Two dark expanded triads (arrows) have fuzzy edges. B. A triad shows interface hepatitis by lymphocytes and macrophages, with surrounding of hepatocytes (black arrows), piecemeal necrosis, with collections in the lobule (green arrows), spotty necrosis. The portal triad, venule and artery (blue arrows) are unaffected. The central vein’s being near the triad with a small pink line (yellow arrows) indicates significant collapse. C. Reticulin. Thick black lines between triad and central vein (blue arrows) document significant necrosis (LN 2). Two-three cell thick cords (green arrows) show regeneration. D. Reticulin. Thick black lines extending from triad, but not to a central vein, (blue arrows) are not as significant. Black lines surrounding multiple hepatocytes (green arrows) indicate moderate piecemeal necrosis (PMN 2), not severe because it does not involve most of the triad of most triads. E. Trichrome. Only fibrosis of portal triads was seen, indicating metavir fibrosis stage 1. | |||
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[[File:1 hcv 6 680x512px.tif|Inflamed bands cross hepatocytes with steatosis (Row 1 Left 40X).]] | [[File:1 hcv 6 680x512px.tif|Inflamed bands cross hepatocytes with steatosis (Row 1 Left 40X).]] | ||