48,830
edits
Difference between revisions of "KRAS mutation"
Jump to navigation
Jump to search
→Microscopic
| Line 21: | Line 21: | ||
Features: | Features: | ||
*Typically [[mucinous carcinoma]] in lung.<ref name=pmid25029118>{{Cite journal | last1 = Kadota | first1 = K. | last2 = Yeh | first2 = YC. | last3 = D'Angelo | first3 = SP. | last4 = Moreira | first4 = AL. | last5 = Kuk | first5 = D. | last6 = Sima | first6 = CS. | last7 = Riely | first7 = GJ. | last8 = Arcila | first8 = ME. | last9 = Kris | first9 = MG. | title = Associations between mutations and histologic patterns of mucin in lung adenocarcinoma: invasive mucinous pattern and extracellular mucin are associated with KRAS mutation. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1118-27 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000246 | PMID = 25029118 }}</ref> | *Typically [[mucinous carcinoma]] in lung.<ref name=pmid25029118>{{Cite journal | last1 = Kadota | first1 = K. | last2 = Yeh | first2 = YC. | last3 = D'Angelo | first3 = SP. | last4 = Moreira | first4 = AL. | last5 = Kuk | first5 = D. | last6 = Sima | first6 = CS. | last7 = Riely | first7 = GJ. | last8 = Arcila | first8 = ME. | last9 = Kris | first9 = MG. | title = Associations between mutations and histologic patterns of mucin in lung adenocarcinoma: invasive mucinous pattern and extracellular mucin are associated with KRAS mutation. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1118-27 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000246 | PMID = 25029118 }}</ref> | ||
*Associated with tumour-infiltrating leukocytes - lung adenocarcinoma.<ref name=pmid23619604>{{Cite journal | last1 = Rekhtman | first1 = N. | last2 = Ang | first2 = DC. | last3 = Riely | first3 = GJ. | last4 = Ladanyi | first4 = M. | last5 = Moreira | first5 = AL. | title = KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma. | journal = Mod Pathol | volume = 26 | issue = 10 | pages = 1307-19 | month = Oct | year = 2013 | doi = 10.1038/modpathol.2013.74 | PMID = 23619604 }}</ref> | |||
*In [[colorectal carcinoma]]: | *In [[colorectal carcinoma]]: | ||
**No correlation in one study.<ref>{{Cite journal | last1 = Gao | first1 = J. | last2 = Zhang | first2 = J. | last3 = Lu | first3 = T. | last4 = Li | first4 = XY. | last5 = Jia | first5 = N. | last6 = Liang | first6 = ZY. | title = [Correlation between KRAS mutations and clinicopathologic features in colorectal carcinomas]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 9 | pages = 595-8 | month = Sep | year = 2012 | doi = | PMID = 23157826 }}</ref> | **No correlation in one study.<ref name=pmid23157826 >{{Cite journal | last1 = Gao | first1 = J. | last2 = Zhang | first2 = J. | last3 = Lu | first3 = T. | last4 = Li | first4 = XY. | last5 = Jia | first5 = N. | last6 = Liang | first6 = ZY. | title = [Correlation between KRAS mutations and clinicopathologic features in colorectal carcinomas]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 9 | pages = 595-8 | month = Sep | year = 2012 | doi = | PMID = 23157826 }}</ref> | ||
**'''Not''' high-grade based on one study.<ref name=pmid24925349>{{Cite journal | last1 = Gonsalves | first1 = WI. | last2 = Mahoney | first2 = MR. | last3 = Sargent | first3 = DJ. | last4 = Nelson | first4 = GD. | last5 = Alberts | first5 = SR. | last6 = Sinicrope | first6 = FA. | last7 = Goldberg | first7 = RM. | last8 = Limburg | first8 = PJ. | last9 = Thibodeau | first9 = SN. | title = Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147. | journal = J Natl Cancer Inst | volume = 106 | issue = 7 | pages = | month = Jul | year = 2014 | doi = 10.1093/jnci/dju106 | PMID = 24925349 }}</ref> | **'''Not''' high-grade based on one study.<ref name=pmid24925349>{{Cite journal | last1 = Gonsalves | first1 = WI. | last2 = Mahoney | first2 = MR. | last3 = Sargent | first3 = DJ. | last4 = Nelson | first4 = GD. | last5 = Alberts | first5 = SR. | last6 = Sinicrope | first6 = FA. | last7 = Goldberg | first7 = RM. | last8 = Limburg | first8 = PJ. | last9 = Thibodeau | first9 = SN. | title = Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147. | journal = J Natl Cancer Inst | volume = 106 | issue = 7 | pages = | month = Jul | year = 2014 | doi = 10.1093/jnci/dju106 | PMID = 24925349 }}</ref> | ||