Difference between revisions of "Glioblastoma"

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47 bytes added ,  08:07, 20 September 2016
→‎IHC: secondary GBM
(→‎General: who 2016 update)
(→‎IHC: secondary GBM)
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*[[MAP2]] +ve.
*[[MAP2]] +ve.
*[[IDH-1]] -ve (95%).
*[[IDH-1]] -ve (95%).
**+ve if developed from lower grade astrocytoma (secondary GBM).
**+ve if developed from lower grade astrocytoma (secondary GBM) -> classify tumor as Glioblastoma, IDH-mutant.
*[[WT-1]] +ve (cytoplasm).
*[[WT-1]] +ve (cytoplasm).
*p53 +ve (70%).
*p53 +ve (70%).
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*panCK -ve (except for GBM with epithelial component).
*panCK -ve (except for GBM with epithelial component).
*[[ATRX]]: +ve (no loss, nuclei)
*[[ATRX]]: +ve (no loss, nuclei)
**-ve if developed from lower grade astrocytoma (secondary GBM).
**-ve if developed from lower grade astrocytoma (secondary GBM).  
*EMA: Dot-like expression less common than in [[ependymoma]]s.
*EMA: Dot-like expression less common than in [[ependymoma]]s.
*MIB-1 usu. 15-30%, but varies greatly.
*MIB-1 usu. 15-30%, but varies greatly.
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