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Difference between revisions of "Dermatologic neoplasms"
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==Dermatofibrosarcoma protuberans== | ==Dermatofibrosarcoma protuberans== | ||
*Abbreviated ''DFSP''. | |||
===General=== | ===General=== | ||
*Dermal location. | *Dermal location. | ||
*Destroys adnexal structures. | *Destroys adnexal structures. | ||
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*Wide excision. | *Wide excision. | ||
=== | ===Microscopic=== | ||
Features: | |||
*Spindle cell morphology. | *Spindle cell morphology. | ||
*Contains adipose tissue within the tumour -- ''key feature''. | *Contains adipose tissue within the tumour -- '''key feature'''. | ||
DDx: | |||
*[[Dermatofibroma]] - has entrapment of collagen bundles at the edge of the lesion. | |||
===IHC=== | ===IHC=== | ||
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**Usually positive in dermatofibroma.<ref name=pmid7694515>{{cite journal |author=Abenoza P, Lillemoe T |title=CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans |journal=Am J Dermatopathol |volume=15 |issue=5 |pages=429–34 |year=1993 |month=October |pmid=7694515 |doi= |url=}}</ref><ref name=pmid9129699>{{cite journal |author=Goldblum JR, Tuthill RJ |title=CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma |journal=Am J Dermatopathol |volume=19 |issue=2 |pages=147–53 |year=1997 |month=April |pmid=9129699 |doi= |url=}}</ref> | **Usually positive in dermatofibroma.<ref name=pmid7694515>{{cite journal |author=Abenoza P, Lillemoe T |title=CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans |journal=Am J Dermatopathol |volume=15 |issue=5 |pages=429–34 |year=1993 |month=October |pmid=7694515 |doi= |url=}}</ref><ref name=pmid9129699>{{cite journal |author=Goldblum JR, Tuthill RJ |title=CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma |journal=Am J Dermatopathol |volume=19 |issue=2 |pages=147–53 |year=1997 |month=April |pmid=9129699 |doi= |url=}}</ref> | ||
*S100 -ve (screen for melanoma). | *S100 -ve (screen for melanoma). | ||
* | *Caldesmin -ve (screen for muscle differentiation). | ||
* | *Beta-catenin. (???) | ||
*MIB-1 (proliferation marker) | *MIB-1 (proliferation marker). | ||
**Should not be confused with ''MIB1'' a gene that regulates [[apoptosis]]. | |||
==Cutaneous B-cell lymphoma== | ==Cutaneous B-cell lymphoma== | ||